Exploration of conditioned pain modulation effect on long‐term potentiation‐like pain amplification in humans

Abstract

Conditioned pain modulation (CPM) may play a role in inhibiting the pain amplificatory process at the central nervous system and prompting central desensitization. CPM has a special inhibition effect for the development of perception amplification to non-painful mechanical stimuli.

Preferential Electrical Stimulation of Small Nociceptive Fibers and Induction of Secondary Hyperalgesia

“…HFS has routinely been used as a model of secondary hyperalgesia (e.g. [25][26][27]101), a phenomenon related to chronic pain. The intense nociceptive signaling to the dorsal horn of the spinal cord potentiates responses in spinal neurons heterosynaptically which can be assessed directly from spinal cord neurons in animals (24).…”