Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells

Hu, Ying-huan; Li, Dengke; Zhengyang, Quan; Wang, Chengyu; Zhou, Ming; Sun, Zhenxiao

doi:10.1016/j.jep.2021.113845

Cited by 14 publications

(2 citation statements)

References 40 publications

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“…In the past year, a study conducted by Hu et.al. identified 2,3,5,4 ′ -tetrahydroxy stilbene glycoside (TSG) and emodin (EM), both compounds found in the dried root of Polygonum multiflorum, as the main causes of Polygonum-multiflorum-induced liver injury [57]. The most widely described pattern of liver injury is hepatocellular, but cases of mixed hepatocellular and cholestatic liver injury have been reported.…”

Section: Black Cohoshmentioning

confidence: 99%

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues,

Cundra,

Alhaqqan

et al. 2024

Livers

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Herbal-induced liver injury (HILI) continues to increase in prevalence each year due to the ongoing popularity of herbal supplements and complementary and alternative medicines. A detailed literature review of case reports and clinical studies published from March 2021 to March 2023 was performed. We discuss the epidemiology and diagnosis of HILI as well as the current and proposed laws and regulations. The 2021 ACG guidelines and 2022 AASLD practice guidelines for the diagnosis and management of drug and herbal-induced liver injury are discussed. We describe updates to previously reported etiologies of HILI such as ayurveda, ashwagandha, turmeric, kratom, green tea extract, and garcinia cambogia. Newly described supplements resulting in HILI, such as tinospora cordifolia, horse chestnut, alkaline water, and more, are described. We discuss newly and previously identified hepatoprotective herbal supplements as they have been reported in the study of animal models and human liver cells. This review suggests the need for ongoing research on the causes and mechanisms of HILI to ensure its proper diagnosis, prevention, and treatment in the future. The goal of this review is to provide novice and expert readers with knowledge regarding the possible etiologies of HILI and a general overview.

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Section: Black Cohoshmentioning

confidence: 99%

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues,

Cundra,

Alhaqqan

et al. 2024

Livers

View full text Add to dashboard Cite

show abstract

“…Research indicates emodin exhibits concentration- and time-dependent cytotoxic effects on normal hepatocytes and hepatocellular carcinoma cells [ 32 , 33 ]. It is noteworthy that the primary mechanism by which emodin exerts hepatocellular cytotoxicity is through inducing apoptosis [ [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , 34 ]. A study in 2016 found that emodin could increase the ratio of Bax/Bcl2 proteins in HepG2 and primary human hepatocytes, leading to disruption of mitochondrial membrane potential (MMP) and consequent mitochondrial damage.…”

Section: Mechanism Of Emodin-induced Hepatotoxicitymentioning

confidence: 99%