Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort

Segura, Álex G.; Mané, Anna; Prohens, Llucia; Rodríguez, Natàlia; Mezquida, Gisela; Cuesta, Manuel J.; Vieta, Eduard; Amoretti, Sílvia; Lobò, Antonio; González‐Pinto, Ana; Díaz‐Caneja, Covadonga M.; Roldán-Bejarano, Alexandra; Jiménez, Esther; Baeza, Immaculada; Legido, Teresa; Sáiz, Pilar A.; Bernardo, Miquel; Mas, Sergi

doi:10.1016/j.psychres.2023.115249

Cited by 1 publication

(1 citation statement)

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“…With respect to CUD, there have only been a few PGS studies. Segura et al [77] found that CUD PGS were significantly associated with cannabis use and monthly cannabis use at baseline, but not with age at initiation of cannabis use or with various measures related to the clinical course after a first-episode psychosis. In contrast, Cheng et al [78] showed that PGS for CUD predicted bipolar disorder with psychotic experience but not bipolar disorder without psychotic experience.…”

Section: Polygenic Prediction Of Substance Use Disordersmentioning

confidence: 99%

The genetic landscape of substance use disorders

Gerring,

Thorp,

Treur

et al. 2024

Mol Psychiatry

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Substance use disorders represent a significant public health concern with considerable socioeconomic implications worldwide. Twin and family-based studies have long established a heritable component underlying these disorders. In recent years, genome-wide association studies of large, broadly phenotyped samples have identified regions of the genome that harbour genetic risk variants associated with substance use disorders. These regions have enabled the discovery of putative causal genes and improved our understanding of genetic relationships among substance use disorders and other traits. Furthermore, the integration of these data with clinical information has yielded promising insights into how individuals respond to medications, allowing for the development of personalized treatment approaches based on an individual’s genetic profile. This review article provides an overview of recent advances in the genetics of substance use disorders and demonstrates how genetic data may be used to reduce the burden of disease and improve public health outcomes.

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Section: Polygenic Prediction Of Substance Use Disordersmentioning

confidence: 99%