Exploration for the reference interval of C-reactive protein in the Chinese longevity people over 90 years of age

Gao, Danni; Ni, Xiaolin; Fang, Sihang; Wang, Zhaoping; Jiao, Juan; Liu, Dizhi; Huang, Xiuqing; Jiang, Mingjun; Zhou, Qi; Sun, Liang; Zhu, Xiaoquan; Su, Huabin; Huang, Bin; Lv, Yuan; Pang, Guofang; Hu, Caiyou; Yang, Ze; Yuan, Huiping

doi:10.1016/j.dsx.2023.102817

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…C-reactive protein (CRP) is synthesized and secreted in hepatocytes and its transcription is mainly under IL-6 control ( 6 ). Increased plasma concentrations of CRP is also associated with aging ( 7 ). It has also been reported that both obese and elderly individuals have higher levels of circulating inflammatory markers ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice

Maejima,

Yokota,

Yamachi

et al. 2024

Front. Endocrinol.

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The high prevalence of obesity has become a pressing global public health problem and there exists a strong association between increased BMI and mortality at a BMI of 25 kg/m2 or higher. The prevalence of obesity is higher among middle-aged adults than among younger groups and the combination of aging and obesity exacerbate systemic inflammation. Increased inflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha (TNFα) are hallmarks of obesity, and promote the secretion of hepatic C-reactive protein (CRP) which further induces systematic inflammation. The neuropeptide oxytocin has been shown to have anti-obesity and anti-inflammation effects, and also suppress sweet-tasting carbohydrate consumption in mammals. Previously, we have shown that the Japanese herbal medicine Kamikihito (KKT), which is used to treat neuropsychological stress disorders in Japan, functions as an oxytocin receptors agonist. In the present study, we further investigated the effect of KKT on body weight (BW), food intake, inflammation, and sweet preferences in middle-aged obese mice. KKT oral administration for 12 days decreased the expression of pro-inflammatory cytokines in the liver, and the plasma CRP and TNFα levels in obese mice. The effect of KKT administration was found to be different between male and female mice. In the absence of sucrose, KKT administration decreased food intake only in male mice. However, while having access to a 30% sucrose solution, both BW and food intake was decreased by KKT administration in male and female mice; but sucrose intake was decreased in female mice alone. In addition, KKT administration decreased sucrose intake in oxytocin deficient lean mice, but not in the WT lean mice. The present study demonstrates that KKT ameliorates chronic inflammation, which is strongly associated with aging and obesity, and decreases food intake in male mice as well as sucrose intake in female mice; in an oxytocin receptor dependent manner.

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Section: Introductionmentioning

confidence: 99%

Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice

Maejima,

Yokota,

Yamachi

et al. 2024

Front. Endocrinol.

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Peripheral CD4 (+) T Cell Immunity and Brain Microglial Activation Associated with Cognitive Heterogeneity in Aged Rats

Yu,

Liu,

Guan

et al. 2024

Preprint

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Cognitive decline is a critical hallmark of brain aging. Although aging is a natural process, there is significant heterogeneity in cognition levels among individuals; however, the underlying mechanisms remain uncertain. In our study, we classified aged male Sprague-Dawley rats into aged cognition-unimpaired (AU) group and aged cognition-impaired (AI) group, by using an attentional set-shifting task. The transcriptome sequencing results of medial prefrontal cortex (mPFC) demonstrated significant differences in microglial activation and inflammatory response pathways between the two groups. Specifically, compared to AU rats, AI rats exhibited a greater presence of CD86-positive microglia and major histocompatibility complex class II (MHC-II)-positive microglia, along with elevated inflammatory molecules, in mPFC. Conversely, AI rats exhibited a reduction in the amount of microglia expressing CD200R and the anti-inflammatory molecules Arg-1 and TGF-β. Additionally, peripheral blood analysis of AI rats demonstrated elevated levels of Th17 and Th1 cells, along with proinflammatory molecules; however, decreased levels of Treg cells, along with anti-inflammatory molecules, were observed in AI rats. Our research suggested that peripheral Th17/Treg cells and central microglial activation were associated with cognitive heterogeneity in aged rats. This may provide a new target for healthy aging.

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Exploration for the reference interval of C-reactive protein in the Chinese longevity people over 90 years of age

Cited by 2 publications

References 35 publications

Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice

Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice

Peripheral CD4 (+) T Cell Immunity and Brain Microglial Activation Associated with Cognitive Heterogeneity in Aged Rats

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