Exploration clinique et biologique du NO

Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection

“…eNOS is essential to vascular homeostasis. Its disturbance is a major contributor to the pathogenesis of vascular disease because NO produced by eNOS regulates vascular diameter, thus flow [38], playing a significant role in vascular relaxation by inhibiting smooth muscle contraction, thereby modulating vascular tone [2,3], and reduces plasma exudation in the airways [39]. Oxidative stress often accompanying airway diseases results in S-nitrosylation, which reduces eNOS enzyme activity in the vascular endothelium [40].…”

“…It has also been shown that the indirect parameters of wave reflection and arterial stiffness, such as Aix can stratify patients with a high risk of cardiac and cerebral events who might benefit from more aggressive cardiovascular treatment [10,11]. The association of vasomotor function, morphological and biomechanical properties of arterial vessels with NO [8,10]-and consequently with FE NO -values was previously suggested [2]; however, it is unclear if FE NO shares a common source of genetic and/or environmental variability with arterial stiffness parameters.…”

“…NO is an inorganic gas widely distributed throughout the body playing important functions in cell physiology. NO, released by endothelial cells, plays a significant role in vascular relaxation by inhibiting smooth muscle contraction and thus modulating vascular tone [2,3].…”

“…In addition to its pulmonary and inflammatory roles, NO seems to play an important role in the regulation of vascular function and structure [2,3]; however, its relationship with the marker of arterial elasticity is still poorly understood. The stiffness of large vessels such as the aorta is an important determinant of systolic and diastolic pressures and wave reflection from the periphery [8].…”