Exploration biases forelimb reaching strategies

Mosberger, Alice C.; Sibener, Leslie J.; Chen, Tiffany X.; Rodrigues, Helio F.M.; Hormigo, Richard; Ingram, James N.; Athalye, Vivek R.; Tabachnik, Tanya; Wolpert, Daniel M.; Murray, James M.; Costa, Rui M.

doi:10.1016/j.celrep.2024.113958

Cell Reports

2024

DOI: 10.1016/j.celrep.2024.113958

|View full text |Cite

Exploration biases forelimb reaching strategies

Alice C. Mosberger,

Leslie J. Sibener,

Tiffany X. Chen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 102 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning

Sheng,

Lu,

Sheng

et al. 2024

Preprint

View full text Add to dashboard Cite

Motor skill learning induces long-lasting synaptic plasticity at not only the inputs, such as dendritic spines1–4, but also at the outputs to the striatum of motor cortical neurons5,6. However, very little is known about the activity and structural plasticity of corticostriatal axons during learning in the adult brain. Here, we used longitudinal in vivo two-photon imaging to monitor the activity and structure of thousands of corticostriatal axonal boutons in the dorsolateral striatum in awake mice. We found that learning a new motor skill induces dynamic regulation of axonal boutons. The activities of motor corticostriatal axonal boutons exhibited selectivity for rewarded movements (RM) and un-rewarded movements (UM). Strikingly, boutons on the same axonal branches showed diverse responses during behavior. Motor learning significantly increased the fraction of RM boutons and reduced the heterogeneity of bouton activities. Moreover, motor learning-induced profound structural dynamism in boutons. By combining structural and functional imaging, we identified that newly formed axonal boutons are more likely to exhibit selectivity for RM and are stabilized during motor learning, while UM boutons are selectively eliminated. Our results highlight a novel form of plasticity at corticostriatal axons induced by motor learning, indicating that motor corticostriatal axonal boutons undergo dynamic reorganization that facilitates the acquisition and execution of motor skills.

show abstract

Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning

Sheng,

Lu,

Sheng

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Exploration biases forelimb reaching strategies

Cited by 1 publication

References 102 publications

Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning

Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning

Contact Info

Product

Resources

About