Exploration and Clinical Verification of the Blood Co-Expression Genes of Type 2 Diabetes Mellitus and Mild Cognitive Dysfunction in the Elderly

Deng, Shengfeng; Zhong, Hongfei; Liu, Miao; Ding, Jingwen; Geng, Rulin; Tu, Qiuyun

doi:10.3390/biomedicines11040993

Cited by 2 publications

(2 citation statements)

References 61 publications

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“… 40 Zhang et al reported that ALDH2 is one of the co-pathogenic genes of T2DM and mild cognitive impairment (MCI). 41 Another study reported that the ALDH2 polymorphism might association with susceptibility to DM and showed a significantly lower risk of T2DM for ALDH2 G/G and G/A genotypes in China. 42 Xu et al found that ALDH2 polymorphism is associated with an increased risk of T2DM in women with coronary artery disease (CAD).…”

Section: Discussionmentioning

confidence: 99%

Association Between ALDH2 Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Zeng,

Liu,

Xie

2023

IJGM

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Background Aldehyde dehydrogenase 2 ( ALDH2 ) polymorphisms have been extensively studied in patients with hypertension (HTN) and diabetes mellitus (DM) in recent years. However, it is unclear whether ALDH2 polymorphisms are correlated with the risk of developing DM in patients with HTN. This study was designed to examine the association between ALDH2 single nucleotide polymorphism (SNP) rs671 and the risks of DM in patients with HTN. Methods This study retrospectively analyzed the patients with HTN who were treated in Meizhou People’s Hospital from August 2016 to December 2020, 788 HTN patients with DM as case patients, and 1632 HTN patients without DM history as controls. ALDH2 polymorphisms were analyzed using a polymerase chain reaction (PCR)-gene chip. Differences in ALDH2 genotypes between subjects and controls were compared. To analyze the relationship between ALDH2 genotype and DM risk, multiple logistic regression analysis was performed after adjusting for gender, age, smoking history, and drinking history. Results The proportion of the G/A plus A/A genotype was significantly higher in patients with DM than in controls (52.8% vs 48.2%, P =0.033). DM patients with G/A genotype had lower LDL-C ( P <0.017) than those with G/G genotype. The results of logistic regression analysis indicated that the G/A genotype increased the risk of DM in HTN patients, with an adjusted odds ratio (OR) of 1.209 (95% confidence interval (CI) 1.010–1.446) ( P =0.038), whereas the G/A plus A/A genotype in the dominant model increased the risk of DM significantly, with an adjusted OR of 1.203 (95% CI 1.013–1.428) ( P =0.035). Conclusion ALDH2 A allele (G/A + A/A genotype) increased the risk of DM in patients with HTN.

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Section: Discussionmentioning

confidence: 99%

Association Between ALDH2 Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Zeng,

Liu,

Xie

2023

IJGM

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“…In women, the presence of estrogenic activity slows down the progression of Parkinson's disease, as the hormone gives these subjects high levels of physiological dopamine at the nigro-striatal level [101]. This suggests that estrogens may have a role in preventing the disease itself due to their anti-inflammatory activity, which counteracts the chronic inflammatory state induced by IR [102,103].…”

Section: Insulin Resistance and Cognitive And Neurological Diseasesmentioning

confidence: 99%

Gender Differences in Insulin Resistance: New Knowledge and Perspectives

Ciarambino,

Crispino,

Guarisco

et al. 2023

CIMB

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Insulin resistance is the main mechanism in a whole series of pathological conditions, which are not only of metabolic interest but also of a systemic type. This phenomenon means that the body’s cells become less sensitive to the hormone insulin, leading to higher levels of insulin in the blood. Insulin resistance is a phenomenon that can be found in both men and women and in particular, in the latter, it is found mainly after menopause. Premenopause, hormonal fluctuations during the menstrual cycle, and the presence of estrogen can affect insulin sensitivity. Androgens, such as testosterone, are typically higher in men and can contribute to insulin resistance. In both sexes, different human body types affect the distribution and location of body fat, also influencing the development of diabetes and cardiovascular disease. Insulin resistance is also associated with some neurological and neurogenerative disorders, polycystic ovary syndrome, atherosclerosis, and some of the main neoplastic pathologies. A healthy lifestyle, including regular physical activity, a balanced diet, and self-maintenance, can help to prevent the onset of insulin resistance, regardless of gender, although the different habits between men and women greatly affect the implementation of preventative guidelines that help in fighting the manifestations of this metabolic disorder. This review may help to shed light on gender differences in metabolic diseases by placing a necessary focus on personalized medical management and by inspiring differentiated therapeutic approaches.

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Exploration and Clinical Verification of the Blood Co-Expression Genes of Type 2 Diabetes Mellitus and Mild Cognitive Dysfunction in the Elderly

Cited by 2 publications

References 61 publications

Association Between ALDH2 Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Association Between ALDH2 Polymorphisms and the Risk of Diabetes Mellitus in Hypertensive Patients

Gender Differences in Insulin Resistance: New Knowledge and Perspectives

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