“…The same effect was observed at the level of luciferase transgene expression, indicating that the DNA/Gal-pOrn vector was not only able to adhere and enter preferentially into hepatocytes, but it could also transfect them. Many different domains of known proteins and sugars have been used for cell targeting of modular vectors, like galactose (Wu and Wu 1987), transferrin (Wagner et al 1990), foot-andmouth disease virus integrin interacting peptide (Aris et al 2000;Aris and Villaverde 2003;Domingo-Espín et al 2011), nerve growth factor Zeng et al 2004), surfactant protein A (Ross et al 1995), rabies virus glycoprotein (Kumar et al 2007), tetanus toxin fragment Hc (Box et al 2003;Knight et al 1999), cholera toxin b chain (Barrett et al 2004), and neurotensin (Navarro-Quiroga et al 2002). In an interesting study, Arango-Rodríguez and colleagues showed that they could target only substantia nigra neurotensin high affinity receptor positive neurons by means of a modular vector that displayed neurotensin, while no other neurons were transfected (Arango-Rodriguez et al 2006).…”