Abstract:This study presents TooT-PLM-ionCT, a composite framework consisting of three distinct systems, each with different architectures and trained on unique datasets. Each system within TooT-PLM-ionCT is dedicated to a specific task: segregating ion channels (ICs) and ion transporters (ITs) from other membrane proteins and differentiating ICs from ITs. These systems exploit the capabilities of six diverse Protein Language Models (PLMs) - ProtBERT, ProtBERT-BFD, ESM-1b, ESM-2 (650M parameters), and ESM-2 (15B parame… Show more
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