Exploiting Polyhydroxyalkanoates for Biomedical Applications

Kalia, Vipin Chandra; Patel, Sanjay; Lee, Jung-Kul

doi:10.3390/polym15081937

Cited by 17 publications

(6 citation statements)

References 173 publications

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“…A PHA, for example, is a polyhydroxybutyrate (PHB), polyhydroxyvalerate (PHV), or a copolymer. Among the most extensively studied and well‐known PHAs is PHB 102–104 …”

Section: Types Of Polymers Used In Coatings For Prosthetics and Implantsmentioning

confidence: 99%

Biopolymer‐based coatings for anti‐corrosion of Ti‐alloys used in biomedical applications: A review

Al‐Mosawi,

Abdulsada

2024

Polymer Engineering & Sci

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There are several enviable attributes of titanium and its alloys that contribute to their popularity in biomedical devices and equipment, including their rather low modulus, excellent corrosion resistance, and biocompatibility, good machinability, formability, and strength comprehensive impact and fatigue. Nevertheless, titanium and its alloys do not meet all medical requirements due to its unique properties and alloys, so surface modifications must be made to enhance mechanical, chemical, and biological characteristics. As a review of biomedical engineering, this article discusses specific polymers for coating applications as well as various polymer coatings for functionalization improvements. The versatility of biopolymer coatings makes them extremely appropriate for a broad range of biological uses. To enhance the engineering of tissue and drug delivery, this study summarized and analyzed the most recent advances in biopolymer coatings. Surface qualities of polymer coatings can be adjusted to meet specific criteria for various biomedical applications or integrated with new capabilities. Moreover, polymer coatings containing different inorganic ions can enhance the growth of tissue, proliferation of cells, healing, as well as the transfer of biomolecules, like active molecules, agents of antimicrobial, factors of growth, and medications.Highlights Surface modification avenues of Ti materials as orthopedic replacements are critically reviewed. Basic descriptions of titanium and titanium alloys are presented. Advances in the corrosion behavior of biomedical titanium alloys are thoroughly scrutinized. Fundamental methods based on mechanical, physical, and chemical principles for biopolymer coatings are particularly presented. Main biopolymer coatings types that are used on titanium surfaces are reviewed.

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“…A PHA, for example, is a polyhydroxybutyrate (PHB), polyhydroxyvalerate (PHV), or a copolymer. Among the most extensively studied and well‐known PHAs is PHB 102–104 …”

Section: Types Of Polymers Used In Coatings For Prosthetics and Implantsmentioning

confidence: 99%

Biopolymer‐based coatings for anti‐corrosion of Ti‐alloys used in biomedical applications: A review

Al‐Mosawi,

Abdulsada

2024

Polymer Engineering & Sci

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“…The replacement of non-biodegradable plastics with biopolymers has been envisaged as an ecofriendly and economical approach, especially for producing high-value products such as those required for the medical sector [107]. Biological processes have several major benefits over conventional chemical processes.…”

Section: Perspectivesmentioning

confidence: 99%

Manipulating Microbial Cell Morphology for the Sustainable Production of Biopolymers

Kalia,

Patel,

Karthikeyan

et al. 2024

Polymers

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The total rate of plastic production is anticipated to surpass 1.1 billion tons per year by 2050. Plastic waste is non-biodegradable and accumulates in natural ecosystems. In 2020, the total amount of plastic waste was estimated to be 367 million metric tons, leading to unmanageable waste disposal and environmental pollution issues. Plastics are produced from petroleum and natural gases. Given the limited fossil fuel reserves and the need to circumvent pollution problems, the focus has shifted to biodegradable biopolymers, such as polyhydroxyalkanoates (PHAs), polylactic acid, and polycaprolactone. PHAs are gaining importance because diverse bacteria can produce them as intracellular inclusion bodies using biowastes as feed. A critical component in PHA production is the downstream processing procedures of recovery and purification. In this review, different bioengineering approaches targeted at modifying the cell morphology and synchronizing cell lysis with the biosynthetic cycle are presented for product separation and extraction. Complementing genetic engineering strategies with conventional downstream processes, these approaches are expected to produce PHA sustainably.

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“…Their organic origins and biodegradability make them a great candidate for drug delivery, biomedical device fabrication, and tissue engineering . Degradation of PHAs results in R-3HA groups that can be transformed to 2-alkylated 3HB or β-lactones, giving rise to antibiotic compounds such as carbapenem or macrolide . Hemoembolizing agents such as rifampicin have also been encapsulated in PHB or PHVB microspheres for controlled drug delivery .…”

Section: Novel Polyesters Utilized In Tissue Engineering and Organs-o...mentioning

confidence: 99%

Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip

Okhovatian,

Shakeri,

Davenport Huyer

et al. 2023

Biomacromolecules

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Cardiovascular tissue constructs provide unique design requirements due to their functional responses to substrate mechanical properties and cyclic stretching behavior of cardiac tissue that requires the use of durable elastic materials. Given the diversity of polyester synthesis approaches, an opportunity exists to develop a new class of biocompatible, elastic, and immunomodulatory cardiovascular polymers. Furthermore, elastomeric polyester materials have the capability to provide tailored biomechanical synergy with native tissue and hence reduce inflammatory response in vivo and better support tissue maturation in vitro. In this review, we highlight underlying chemistry and design strategies of polyester elastomers optimized for cardiac tissue scaffolds. The major advantages of these materials such as their tunable elasticity, desirable biodegradation, and potential for incorporation of bioactive compounds are further expanded. Unique fabrication methods using polyester materials such as micromolding, 3D stamping, electrospinning, laser ablation, and 3D printing are discussed. Moreover, applications of these biomaterials in cardiovascular organ-on-a-chip devices and patches are analyzed. Finally, we outline unaddressed challenges in the field that need further study to enable the impactful translation of soft polyesters to clinical applications.

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Exploiting Polyhydroxyalkanoates for Biomedical Applications

Cited by 17 publications

References 173 publications

Biopolymer‐based coatings for anti‐corrosion of Ti‐alloys used in biomedical applications: A review

Biopolymer‐based coatings for anti‐corrosion of Ti‐alloys used in biomedical applications: A review

Manipulating Microbial Cell Morphology for the Sustainable Production of Biopolymers

Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip

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