Exploiting natural anti-tumor immunity for metastatic renal cell carcinoma

Murphy, Katherine A.; James, Britnie R.; Guan, Yue; Torry, Donald S.; Wilber, Andrew; Griffith, Thomas S.

doi:10.1080/21645515.2015.1035849

Cited by 19 publications

(21 citation statements)

References 147 publications

(117 reference statements)

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“…RCC lesions are often in ltrated by high levels of tumor-in ltrating fi fi lymphocytes. The parallel clinical observations of spontaneous tumor regression in some RCC patients has suggested a critical role for immune system in development and regulation of the neoplastic disease [71].…”

Section: Role Of Tils In Renal Cell Carcinoma (Rcc)mentioning

confidence: 94%

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

Badalamenti

Fanale

Incorvaia

et al. 2019

Cellular Immunology

188

151

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Section: Role Of Tils In Renal Cell Carcinoma (Rcc)mentioning

confidence: 94%

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

Badalamenti

Fanale

Incorvaia

et al. 2019

Cellular Immunology

188

151

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“…Several works have reported the presence of NK cells in RCC [139][140][141][142][143] where they may represent a critical component of the anti-tumor response as shown by the association of the NK cell infiltrate with patients' survival [140,141,[144][145][146][147][148]. NK cells also infiltrate RCC lung metastasis, and high NK numbers have been associated with improved survival [145].…”

Section: Nk Cells and Renal Cell Carcinomamentioning

confidence: 99%

“…Adoptive cell therapy has also been used for the treatment of metastatic RCC. Infusion of activated NK cells in combination with IL-2 [81,202,203], and the adoptive transfer of allogeneic NK cells [77] and NK cell lines, such as NK-92 [204], have been tested [142,205]. Infusions of NK cells have also been combined with other therapeutic procedures.…”

Section: Nk Cells and Renal Cell Carcinomamentioning

confidence: 99%

NK Cell-Based Immunotherapy in Renal Cell Carcinoma

Terrén

Orrantia

Mikelez-Alonso

et al. 2020

Cancers

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Natural killer (NK) cells are cytotoxic lymphocytes that are able to kill tumor cells without prior sensitization. It has been shown that NK cells play a pivotal role in a variety of cancers, highlighting their relevance in tumor immunosurveillance. NK cell infiltration has been reported in renal cell carcinoma (RCC), the most frequent kidney cancer in adults, and their presence has been associated with patients’ survival. However, the role of NK cells in this disease is not yet fully understood. In this review, we summarize the biology of NK cells and the mechanisms through which they are able to recognize and kill tumor cells. Furthermore, we discuss the role that NK cells play in renal cell carcinoma, and review current strategies that are being used to boost and exploit their cytotoxic capabilities.

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“…Regardless of the category, kidney tumors have been associated with immune dysfunction [1][2][3]5]. RCCs are rich in immune infiltrates consisting of T cells, natural killer (NK), DCs, macrophages among others [6,7]. Different functions are ascribed to the different subsets of leukocytes.…”

Section: Introductionmentioning

confidence: 99%

“…For example, tumor-associated macrophages (TAMs) are known for their immunosuppressive action, which is associated to the secretion of inhibitory cytokines, the generation of reactive oxygen species, regulatory T cells (Treg) development, and the induction of angiogenesis [6,8,9]. Likewise, myeloid-derived suppressor cells (MDSCs) have been reported preventing the formation and execution of an effective antitumor immune response by the inhibition of effector T-cell function and the induction of Tregs maturation [6,7], besides the inhibition of DC maturation and DC-induced T-cell activation and antitumor cytotoxic T lymphocyte (CTL) [10].…”

Section: Introductionmentioning

confidence: 99%

Role of Immune System in Kidney Cancer

Chudzinski-Tavassi¹,

Morais²,

Souza³

et al. 2020

Evolving Trends in Kidney Cancer

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Almost all kidney cancers are associated to immune dysfunction. Among these, renal cell carcinoma (RCC) represents approximately 2% of malignancies that affect adults and for 90-95% of all kidney cancers. Recent evidences have collaborated to elucidate the mechanisms involved in the development of this disease. In this view, dysfunctional neutrophil migration, as well as T lymphocyte-DC (dendritic cell) cross talk, DC maturation, immune cell metabolism, and reactivity and abnormal expression of cytokines and chemokines and their receptors have been highlighted in RCC and stroma cells. A rational development of novel therapies to recover antitumor activity of immune system is closely related to the understanding of the complex interactions between immune system and tumor. Some insights have been reached and immunomodulatory molecules, such as interleukin-2 (IL-2) and IFN-α, immune checkpoint inhibitors, and chemokines antagonists have shown clinical efficacy. In this chapter, we overview the essential role of innate and adaptive immune response in RCC and discuss drugs approved or in development for its treatment.

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Exploiting natural anti-tumor immunity for metastatic renal cell carcinoma

Cited by 19 publications

References 147 publications

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

NK Cell-Based Immunotherapy in Renal Cell Carcinoma

Role of Immune System in Kidney Cancer

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