Exploiting nanofibrous chitin microspheres as heterogeneous photocatalysts for high throughput PET-RAFT polymerization and bioconjugation

Guo, Wanwu; Zhou, Yan; Duan, Bo; Wu, Wei; Chen, Chen; Li, Xue; Cai, Tao

doi:10.1016/j.cej.2021.132120

Cited by 21 publications

(17 citation statements)

References 45 publications

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“…For oxygen tolerance, however, they required significant amounts of sacrificial reducing agents, such as tertiary amines and ascorbic acid, and did not exhibit full-spectrum absorption. More examples of previously reported PC systems for PET-RAFT polymerizations that satisfy either of those requirements are summarized in Figure S1. ,− …”

Section: Introductionmentioning

confidence: 99%

Silver Sulfide Nanocrystals as a Biocompatible and Full-Spectrum Photocatalyst for Efficient Light-Driven Polymerization under Aqueous and Ambient Conditions

Song

Kim

et al. 2022

ACS Catal.

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Owing to current global environmental concerns, polymers must be prepared under eco-friendly reaction conditions based on sustainable chemistry. In this context, highly efficient photoinduced energy/electron transfer reversible addition− fragmentation chain-transfer (PET-RAFT) polymerization under ambient/aqueous conditions without additives and/or with the aid of sunlight is the optimal approach for producing polymers with well-defined structures. This can be accomplished with a photocatalyst (PC) that utilizes the full spectrum of sunlight for maximum efficiency and has excellent water solubility or dispersibility, oxygen tolerance, and biocompatibility. However, a PC with all of these features has not yet been developed. In this study, we confirmed that this could be achieved using Ag 2 S nanocrystals (NCs) as photocatalysts. The sufficient reducing power of Ag 2 S NCs enabled the successful aqueous PET-RAFT polymerization of numerous acrylic monomers under ambient natural sunlight illumination without any additives. Under illumination, the small band gap of Ag 2 S NCs suppressed the generation of singlet oxygen, resulting in low cytotoxicity toward three different cell lines. Finally, we demonstrated that PET-RAFT polymerization with Ag 2 S NCs can be accomplished in biologically relevant media under natural sunlight illumination, indicating adequate biocompatibility and efficacy of the system.

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Section: Introductionmentioning

confidence: 99%

Silver Sulfide Nanocrystals as a Biocompatible and Full-Spectrum Photocatalyst for Efficient Light-Driven Polymerization under Aqueous and Ambient Conditions

Song

Kim

et al. 2022

ACS Catal.

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“…12,29,[31][32][33] Heterogeneous photocatalysis is a viable alternative: [34][35][36][37][38][39][40][41] the ability to reuse catalysts for multiple reactions mitigates catalyst impurities, and improves both sustainability and cost effectiveness considering the often prohibitively expensive nature of some catalysts (e.g., Ir( ppy) 3 ). 12,18 Recent heterogeneous photocatalytic systems have been based on nanoparticles, [42][43][44][45][46][47][48][49][50][51] polymer networks, [52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] metal oxides, [68][69][70][71][72] or catalytic (single chain nanoparticle) polymers. 73,74…”

Section: Introductionmentioning

confidence: 99%

“…, Ir(ppy) 3 ). 12,18 Recent heterogeneous photocatalytic systems have been based on nanoparticles, 42–51 polymer networks, 52–67 metal oxides, 68–72 or catalytic (single chain nanoparticle) polymers. 73,74 However, nanoparticles themselves strongly absorb visible light and reduce light penetration into the reaction mixture.…”

Section: Introductionmentioning

confidence: 99%

Reusable polymer brush-based photocatalysts for PET-RAFT polymerization

et al. 2022

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“…[20][21][22][23] The implementation of metalloporphyrins in bio-systems is rare, since most catalysts in use have been confined to water-soluble organic pigments such as pheophorbide 𝛼 and eosin Y. [24,25] When screening polymers for biological applications, catalysts removal is often a decisive step toward their production, characterization and practical applications, especially for the multi-well plates used in most biological testing. Otherwise, chemical dyeing and complicated purification create a process bottleneck.…”

Section: Introductionmentioning

confidence: 99%

Development of High Throughput Photopolymerizations Using Micron‐Sized Ultrathin Metal‐Organic Framework Nanosheets

Huang

Guo

et al. 2022

Macromol. Rapid Commun.

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Polymer syntheses in a high throughput format are still challenging due to the tedious procedures for prior deoxygenation and catalyst removal. 2D metal‐organic framework (MOF) nanosheets are advantageous for elevating the catalytic efficiency and catalyst recyclability. Polymerization of a wide variety of monomers, including hydrophilic acrylamides and hydrophobic acrylates, is attempted directly in a multi‐well plate by employing Zn‐ZnPPF‐2D nanosheets (PPF = porphyrin paddlewheel framework) as a heterogeneous photocatalyst. Various parameters such as monomer concentration, catalyst concentration, and light wavelength are investigated with respect to their effects on polymerization rate and the degree of control over the molecular weight and molecular weight distribution. Due to the larger surface area and more accessible catalytic sites, the top‐performing Zn‐ZnPPF‐2D exhibits fast polymerization kinetics over the Zn‐ZnPPF‐3D bulk crystals. In addition, the synthesis of triblock copolymers with a single loading of catalysts confirms the outstanding catalytic performance of these 2D MOF catalysts. Finally, photopolymerization is demonstrated to be achievable entirely in a microliter‐scale human cell culture medium. As such, this strategy provides high levels of control and precision over macromolecular synthesis outcomes that best align with the requirements of high throughput approaches toward biological applications.

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Exploiting nanofibrous chitin microspheres as heterogeneous photocatalysts for high throughput PET-RAFT polymerization and bioconjugation

Cited by 21 publications

References 45 publications

Silver Sulfide Nanocrystals as a Biocompatible and Full-Spectrum Photocatalyst for Efficient Light-Driven Polymerization under Aqueous and Ambient Conditions

Silver Sulfide Nanocrystals as a Biocompatible and Full-Spectrum Photocatalyst for Efficient Light-Driven Polymerization under Aqueous and Ambient Conditions

Reusable polymer brush-based photocatalysts for PET-RAFT polymerization

Development of High Throughput Photopolymerizations Using Micron‐Sized Ultrathin Metal‐Organic Framework Nanosheets

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