Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol (3,4,5)-trisphosphate at sub-nanomolar concentrations

Abstract

Cationic, monolayer-protected gold nanoparticles provide a multivalent charged surface and a hydrophobic monolayer that synergically contribute to the binding of phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a relevant biomarker. The observed dissociation constant...