Acoustic non-reciprocity has been shown to enable a plethora of effects analogous to phenomena seen in quantum physics and electromagnetics, such as immunity from back-scattering and unidirectional band gaps, which could lead to the design of direction-dependent acoustic devices. One way to break reciprocity is by spatiotemporally modulating material properties, which breaks parity and time-reversal symmetries. In this work, we present a model for a medium in which a slow, nonlinear deformation modulates the effective material properties for small, overlaid disturbances (often referred to as 'small-on-large' propagation). The medium is modeled as a discrete spring-mass chain that undergoes large deformation via prescribed displacements of certain points in the unit cell. A multiple-scale perturbation analysis shows that, for sufficiently slow modulations, the small-scale waves can be described by a linear, monatomic chain with time-and space-dependent on-site stiffness. The modulation depth can be tuned by changing the geometric and stiffness parameters of the unit cell. The accuracy of the small-on-large approximation is demonstrated using direct numerical simulations.