Exploiting LIBS as a spectrochemical analytical technique in diagnosis of some types of human malignancies

El-Hussein, Ahmed; Kassem, A.K.; Ismail, H.; Harith, M. A.

doi:10.1016/j.talanta.2010.04.064

Cited by 96 publications

(67 citation statements)

References 10 publications

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“…Examples include the analysis of liver samples from suspected Wilson's disease patients for their Cu content [137], and elemental mapping of murine kidneys for the study of renal clearance [138]. LIBS has also been used to characterize human malignant cells [139]. Quantitative human blood and urine [40] and hair and fingernail [140,141] analysis are also among the continuously tested medical LIBS applications intended to provide information on the exposure or health status of patients.…”

Section: Biological and Biomedical Applicationsmentioning

confidence: 99%

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

Galbács

2015

Anal Bioanal Chem

168

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Laser-induced breakdown spectroscopy (LIBS) has become an established analytical atomic spectrometry technique and is valued for its very compelling set of advantageous analytical and technical characteristics. It is a rapid, versatile, non-contact technique, which is capable of providing qualitative and quantitative analytical information for practically any sample, in a virtually non-destructive way, without any substantial sample preparation. The instrumentation is simple, robust, compact, and even enables remote analysis. This review attempts to give a critical overview of the diverse progress of the field, focusing on the results of the last five years. The advancement of LIBS instrumentation and data evaluation is discussed in detail and selected results of some prominent applications are also described.

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Section: Biological and Biomedical Applicationsmentioning

confidence: 99%

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

Galbács

2015

Anal Bioanal Chem

168

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“…We have summarized a list of the most recent biomedical applications of LIBS in Table I. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] In the following sections, the most recent developments and future prospects of LIBS for the study of biological samples, particularly in the field of biomedical science, have been elaborated. [36] increasing and well-established use of lasers in clinical dental practice, LIBS earlier was recognized as a potentially useful tool for the analysis of calcified tissues such as teeth, particularly for the ability to discriminate caries tissue from healthy tooth tissue but also to monitor the accumulation of trace metals in teeth.…”

Section: Biomedical Applications Of Libsmentioning

confidence: 99%

“…LIBS technique has also been used to distinguish effectively normal and malignant tumour cells from histological sections 56 and to characterize several types of human malignancies. 29 It has also been used to determine the trace metal concentrations in human hair and skin samples [57][58][59] and to determine the elemental composition of liver, kidney, muscle, and hepatopancreas tissues, 60 and even to perform screening of whole human blood. 32 De Souza et al 61 used LIBS technique to investigate the relative elemental composition of chick myocardium tissue.…”

Section: Libs Of Soft Tissuesmentioning

confidence: 99%

Importance of Laser Induced Breakdown Spectroscopy for Biomedical Applications: A Comprehensive Review

Singh¹,

Kumar²,

Sharma³

et al. 2014

mater focus

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Applications of laser-induced breakdown spectroscopy (LIBS) are growing rapidly and continue to extend its horizon to include a broad variety of materials. The recent progress made in the field has transformed LIBS from being an elemental analysis technique to the one applicable for the analysis of molecularly complex biological samples and specimens. LIBS has thus, proven its capability as detection, characterization and identification tool for studying a range of biological specimens and biomaterials. A review is presented here to discuss recent developments and future potential of LIBS and its viability for possible biomedical applications.

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“…LIBS has been used in several applications as the analysis of geological samples [16], environmental monitoring [17], process control [18], archeological artifacts [19,20] and most recently, in space exploration [21]. Furthermore, LIBS was used in characterization and differentiation of tissues [22], bacteria [23], normal and malignant tissues [24,25] and detection of biological agents [26].…”

Section: Introductionmentioning

confidence: 99%

Differentiation of fibrotic liver tissue using laser-induced breakdown spectroscopy

Terán-Hinojosa¹,

Sobral²,

Sánchez‐Pérez³

et al. 2017

Biomed. Opt. Express

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Hepatic cirrhosis is a major cause of morbidity and mortality worldwide due to hepatitis C, alcoholism and fatty liver disease associated with obesity. Assessment of hepatic fibrosis relies in qualitative histological evaluation of biopsy samples. This method is timeconsuming and depends on the histopathologists' interpretation. In the last decades, noninvasive techniques were developed to detect and monitor hepatic fibrosis. Laser-induced breakdown spectroscopy (LIBS) is a good candidate for a real-time, independent and fast technique to diagnose hepatic fibrosis. In this work LIBS was employed to characterize rat liver tissues with different stages of fibrosis. Depth profiling measurements were carried out by using a nanosecond Nd:YAG laser operated at the fundamental wavelength and an echelle spectrometer coupled with an ICCD camera. Due to the soft nature of the samples, plasma conditions largely change between consecutives shots. Thus, a theoretically supported procedure to correct the spectral line intensities was implemented. This procedure allows the reduction of the intensities' dispersion from 67% to 12%. After the correction, the LIBS signal shows an enhancement in calcium intensity by a factor of three as the fibrosis progressed. Calcium is known to increase crosslinking of extracellular matrix proteins in the fibrous septa. Therefore, our result singles it out as a key participant in the hepatic fibrosis.

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Exploiting LIBS as a spectrochemical analytical technique in diagnosis of some types of human malignancies

Cited by 96 publications

References 10 publications

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

A critical review of recent progress in analytical laser-induced breakdown spectroscopy

Importance of Laser Induced Breakdown Spectroscopy for Biomedical Applications: A Comprehensive Review

Differentiation of fibrotic liver tissue using laser-induced breakdown spectroscopy

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