Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer

Blondel, Alice; Benberghout, Amine; Pedeux, Rémy; Ricordel, Charles

doi:10.3390/cancers11101601

Cited by 7 publications

(2 citation statements)

References 83 publications

(118 reference statements)

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“…While the ING2 protein is a chromatin reader and a stable member of the mSin3A/HDAC complex, other studies have connected it to lung cancer. ING2 expression was lost in various cancer subtypes, but it was still discovered to have a variety of tumor-suppressive effects in cancer cell lines (Blondel et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

DNA Profiling of ING1 Gene in Triple Negative Breast Cancer

EZZET,

KARAGOZ,

CANGI

et al. 2023

EPSTEM

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Breast cancer is among the most common cancers and the second in death caused from cancers in women. Triple negative breast cancer (TNBC) is a subgroup which not expressed estrogen (ER), progesterone (PR) and HER2 receptors in breast cancer. It has 15% rate of all breast cancer and has been more aggressive and has poor prognosis. For this reason, early diagnosis has a key role because of TNBC's high relapse. Investigation of DNA methylation pattern in TNBC likewise all types of breast cancer has become an important prognostic vehicle besides assessment of gene expression profile in diagnosis cancer subtypes. DNA methylation pattern of tumor suppressor genes which is one of the epigenetic modifications has highly importance. In this study, we aimed to investigate the relationship DNA methylation pattern of ING1 (inhibitor of growth family member 1), a tumor suppressor gene and TNBC. For this purpose, we searched the methylation pattern of ING1 and breast cancer patients especially TNBC. As a result, we discussed and tried to clarified the relationship between epigenetic modifications of ING1 gene and TNBC.

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Section: Resultsmentioning

confidence: 99%

DNA Profiling of ING1 Gene in Triple Negative Breast Cancer

EZZET,

KARAGOZ,

CANGI

et al. 2023

EPSTEM

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“…Using a high-throughput tissue microarray approach consisting of benign prostate hyperplasia and prostate cancer samples, we have validated that ING3 protein levels are elevated in prostate cancer, corresponding to cBioPortal genomic data [ 32 ]. Moreover, although altered in non-small-cell lung cancers, ING2 seems to be required for cancer proliferation [ 70 ]. In other words, the expression of ING proteins in cancer does not always correlate with cell proliferation.…”

Section: Ing Family Roles In Cancermentioning

confidence: 99%

ING Proteins: Tumour Suppressors or Oncoproteins

Jacquet

Binda

2021

Cancers

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The INhibitor of Growth family was defined in the mid-1990s by the identification of a tumour suppressor, ING1, and subsequent expansion of the family based essentially on sequence similarities. However, later work and more recent investigations demonstrate that at least a few ING proteins are actually required for normal proliferation of eukaryotic cells, from yeast to human. ING proteins are also part of a larger family of chromatin-associated factors marked by a plant homeodomain (PHD), which mediates interactions with methylated lysine residues. Herein, we discuss the role of ING proteins and their various roles in chromatin signalling in the context of cancer development and progression.

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