Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy

Abdelrady, Hend; Hathout, Rania M.; Osman, Rihab; Saleem, Imran; Mortada, Nahed D.

doi:10.1016/j.ejps.2019.03.016

Cited by 78 publications

(24 citation statements)

References 55 publications

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“…This higher interaction may result in a higher loading potential and more sustained release effect of HCQ, specifically, from the gelatin matrix. Gelatin has been rationally selected as the nanoparticulate matrix material for loading the investigated drugs due to its high biocomptability, suitability for nasal and pulmonary delivery, mucoadhesive properties and its efficiency on loading several hydrophilic and hydrophobic drugs [ 1 , 22 , 42 ]. The successful construction of the gelatin matrix using the adopted molecular dynamics method was obtained after following the same protocols of the authors previous studies [ 23 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Chloroquine and hydroxychloroquine for combating COVID-19: Investigating efficacy and hypothesizing new formulations using Bio/chemoinformatics tools

Hathout

AbdelHamid

Metwally

2020

Informatics in Medicine Unlocked

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Chloroquine (CQ) and hydroxychloroquine (HCQ) are undergoing several clinical trials for evaluating their efficacy and safety as antiviral drugs. Yet, there is still a great debate about their efficacy in combating COVID-19. This study aimed to evaluate the feasibility of intranasal and/or pulmonary administration of CQ/HCQ for COVID-19 using Bio/chemoinformatics tools. We, hereby, hypothesize the success of the intranasal and the pulmonary routes through a gelatin matrix to overcome several challenges related to CQ and HCQ pharmacodynamics and pharmacokinetics properties and to increase their local concentrations at the sites of initial viral entry while minimizing the potential side effects. Molecular docking on the gelatin-simulated matrix demonstrated high loading values and a sustained release profile. Moreover, the docking on mucin as well as various receptors including Angiotensin-converting enzyme 2 (ACE-2), heparin sulphate proteoglycan and Phosphatidylinositol binding clathrin assembly protein (PICALM), which are expressed in the lung and intranasal tissues and represent initial sites of attachment of the viral particles to the surface of respiratory cells, has shown good binding of CQ and HCQ to these receptors. The presented data provide an insight into the use of a novel drug formulation that needs to be tested in adequately powered randomized controlled clinical trials; aiming for a sustained prophylaxis effect and/or a treatment strategy against this pandemic viral infection.

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Section: Resultsmentioning

confidence: 99%

Chloroquine and hydroxychloroquine for combating COVID-19: Investigating efficacy and hypothesizing new formulations using Bio/chemoinformatics tools

Hathout

AbdelHamid

Metwally

2020

Informatics in Medicine Unlocked

Self Cite

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“…They concluded that the efficacy of MTX anticancer therapy can be decreased by ASA and, due to that application, these two medications together should be avoided. The novel and effective way of MTX pulmonary delivery in case of lung cancer treatment has been designed by Abdelrady et al [226]. The authors designed and tested the application of MTX-gelatine nanoparticles obtained in different MTX loading techniques.…”

Section: Methotrexate-based Therapy Of Lung Cancermentioning

confidence: 99%

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Koźmiński

Halik

Chesori

et al. 2020

IJMS

204

120

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Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer’s disease or myasthenia gravis will be discussed.

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“…Also, changing the way of administration is also one of the strategies to reduce systemic toxicity. Inhaled delivery, a way that has been widely used in respiratory disease such as asthma, has been reported about delivering chemotherapeutic drugs as a promising administration way for lung cancer including the nanocarriers based on dendrimer, [ 44 ] gelatin, [ 45 ] liposome, [ 46 ] etc.…”

Section: Nanotechnology In the Treatment Of Lung Cancermentioning

confidence: 99%

Nanotechnology: Breaking the Current Treatment Limits of Lung Cancer

Liang

et al. 2021

Adv Healthcare Materials

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Lung cancer is one of the most rapidly growing malignancies in terms of morbidity and mortality. Although traditional treatments have been used for more than 50 years, it is still far from solving the problems of postoperative risks and systemic toxicity. Emerging targeting and immunotherapy are developing continuously and are gaining recognition; eventually, they face the inevitable challenge of drug resistance. Nanotechnology has several important effects on lung cancer treatment, owing to its unique properties. Several nanoparticle‐based treatments have successfully become cancer treatments. Good biocompatibility with higher specific surface area can carry substantial amounts of lung cancer treatment medications while avoiding medication toxicity; editable and modified characteristics give rise to multifunctional nanomedicines; excellent photoelectric effects make lung cancer a multimodal treatment. This article summarizes the breakthroughs achieved by nanotechnology, targeted therapy, and immunotherapy, reflecting the importance and necessity of nanotechnology in the treatment of lung cancer.

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Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy

Abstract: Exploiting gelatin nanocarriers in the pulmonary delivery of methotrexate for lung cancer therapy.

Cited by 78 publications

References 55 publications

Chloroquine and hydroxychloroquine for combating COVID-19: Investigating efficacy and hypothesizing new formulations using Bio/chemoinformatics tools

Chloroquine and hydroxychloroquine for combating COVID-19: Investigating efficacy and hypothesizing new formulations using Bio/chemoinformatics tools

Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers

Nanotechnology: Breaking the Current Treatment Limits of Lung Cancer

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