Exploiting films based on pectin extracted from yellow mombin (Spondias mombin L.) peel for active food packaging

Júnior, Sérgio Dantas de Oliveira; Araújo, Jaciara Silva de; Asevedo, Estéfani Alves; Medeiros, Fábio Gonçalves Macêdo de; Santos, Vinícius Silva dos; Júnior, Francisco Canindé de Sousa; Araújo, Nathália Kelly de; Santos, Everaldo Silvino dos

doi:10.1007/s13399-021-01321-3

Cited by 9 publications

(3 citation statements)

References 71 publications

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“…As the films with PL:PC ratio 2:3 showed more compact topography and lesser number of holes, we infer that this might be due to higher PC percentage, which can form more compact layers. These kinds of features observed in our AFM results for the PS loaded films match with that of drug loaded PC or other polymerbased films [39]. The overall roughness observed on the films with PL-PC, may be because of the degree of esterification of the PC [39].…”

Section: Discussionsupporting

confidence: 77%

“…These kinds of features observed in our AFM results for the PS loaded films match with that of drug loaded PC or other polymerbased films [39]. The overall roughness observed on the films with PL-PC, may be because of the degree of esterification of the PC [39]. Further, the surface roughness seems to increase with the increase in PL concentration, which may be due to the rise of the size of PL micelle [40].…”

Section: Discussionsupporting

confidence: 77%

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Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus

Chakraborty,

Shukla,

Rastogi

et al. 2024

Biomed. Mater.

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Antimicrobial wound dressings play a crucial role in treatment of wound infections. However, existing commercial options fall short due to antibiotic resistance and the limited spectrum of activity of newly emerging antimicrobials against bacteria that are frequently encountered in wound infections. Antimicrobial photodynamic therapy (aPDT) is very promising alternative therapeutic approach against antibiotic resistant microbes such as methicillin resistant Staphylococcus aureus (MRSA). However, delivery of the photosensitizer (PS) homogeneously to the wound site is a challenge. Though polymeric wound dressings based on synthetic and biopolymers are being explored for aPDT, there is paucity of data regarding their in vivo efficacy. Moreover, there are no studies on use of PS loaded, pluoronic (PL) and pectin (PC) based films for aPDT. We report development of a polymeric film for potential use in aPDT. The film was prepared using PL and PC via solvent casting approach and impregnated with Methylene blue (MB) for photodynamic inactivation of MRSA in vitro and in vivo. AFM imaging of the films yielded vivid pictures of surface topography, with rough surfaces, pores, and furrows. The PL:PC ratio (2:3) was optimized that would result in an intact film but exhibit rapid release of MB in time scale suitable for aPDT. The film showed good antibacterial activity against planktonic suspension, biofilm of MRSA upon exposure to red light. Investigations on MRSA infected excisional wounds of mice reveal that topical application of MB loaded film for 30 min followed by red light exposure for 5 min (fluence; ~30 J/cm2) or 10 min (fluence; ~60 J/cm2) reduces ~80 or ∼92% of bioburden, respectively. Importantly, the film elicits no significant cytotoxicity against keratinocytes and human adipose derived mesenchymal stem cells. Taken together, our data demonstrate that PS-loaded PL-PC based films are a promising new tool for treatment of MRSA infected wounds.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 77%

Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus

Chakraborty,

Shukla,

Rastogi

et al. 2024

Biomed. Mater.

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“…Brazil plum ( Spondias tuberosa ) is a drupe‐like, spherical, or ovoid fruit, 4 cm in diameter (dia), with medium‐thick, smooth skin and color that varies from green to pale yellow (Silva et al., 2018). These fruits are rich in bioactive compounds, such as flavonoids, vitamins, and total phenolic content (TPC), which can be associated with biological actions, such as antioxidant, antimicrobial, and antidiabetic activities (Oliveira Júnior et al., 2023; Schiassi et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Flours from Spondias mombin and Spondias tuberosa seeds: Physicochemical characterization, technological properties, and antioxidant, antibacterial, and antidiabetic activities

Oliveira,

Holanda,

de Assis

et al. 2023

Journal of Food Science

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Yellow mombin (Spondias mombin) and Brazil plum (Spondias tuberosa) seeds are byproducts of exploiting their pulp and currently have no relevant food or industrial applications. Thus, the present study aimed to evaluate the physicochemical, technological, and functional characteristics of flours obtained from yellow mombin (YMF) and Brazil plum (BPF) residues. The flours presented a high percentage of insoluble fiber (68.8–70.2 g/100 g) and low carbohydrate (2.7–4.0 g/100 g) and caloric (91.9–95.3 kcal) values. The flours showed potential for technological application. In addition, the highest concentration of total phenolic content (31.1–50.2 mg GAE/g) was obtained with 70% acetone, which provided excellent results for antioxidant capacity evaluated by 2,2′‐azinobis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (81.0%–89.7%) and 2,2‐diphenyl‐1‐picrylhydrazyl (60.6%–69.1%) radical scavenging capacity assays. Flour extracts in 70% acetone also exhibited inhibition of α‐amylase (63.3%–78.8%) and amyloglucosidase (63.5%–71.0%). The antibacterial study revealed that extracts inhibited the growth of Escherichia coli, Burkholderia cepacia, and Burkholderia multivorans. Therefore, this study suggests the use of yellow mombin and Brazil plum residues for different food or industrial applications.Practical ApplicationThe knowledge gained from this study will open a new approach to add value to yellow mombin and Brazil plum fruit seeds as sources of fiber and bioactive compounds, with promising application in the formulation of functional and nutraceutical products, benefiting both a sustainable environment and a sustainable industry.

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Edible films and coatings for food packaging applications: a review

et al. 2021

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Exploiting films based on pectin extracted from yellow mombin (Spondias mombin L.) peel for active food packaging

Cited by 9 publications

References 71 publications

Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus

Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus

Flours from Spondias mombin and Spondias tuberosa seeds: Physicochemical characterization, technological properties, and antioxidant, antibacterial, and antidiabetic activities

Edible films and coatings for food packaging applications: a review

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