Abstract:New ways of curbing the ability of bacteria to evolve spontaneous resistance could 10 mitigate the looming antibiotic resistance crisis. Progress toward this goal requires a comprehensive understanding of the key factors that contribute to resistance evolvability. Here, we present a systematic approach to identify cellular functions that affect the evolvability of resistance. Using a robotic lab-evolution platform that keeps population size and selection pressure under tight control for hundreds of Escherichia… Show more
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