Explanatory factors of quality of life in psychogenic non-epileptic seizure

Gagny, Marion; Grenevald, Louise; El‐Hage, Wissam; Chrusciel, Jan; Sanchez, Stéphane; Schwan, Raymund; Klemina, Irina; Biberon, Julien; Toffol, Bertrand de; Thiriaux, Anne; Visseaux, Jean François; Martin, Martine Lemeles; Meyer, M.P.H. Roger J.; Maillard, Louis; Hingray, Coraline

doi:10.1016/j.seizure.2020.10.028

Cited by 8 publications

(12 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observational period of the present study might be too short to improve the employment status. In view of QoL, structured psychosocial assessments were mostly lacking at the initial examination in previous studies, except for some exceptions 14,37,40 . While Bodde et al 40 demonstrated a positive evolution of QoL, in agreement with the present study, Mayor et al 37 denied that.…”

Section: Discussionsupporting

confidence: 86%

“…However, direct comparisons between baseline and follow‐up data were not presented, because they focused on the evolution of seizure frequency 51 or QoL. 14 Additionally, a prospective study of child patients published recently, which included cases of possible PNES as in this study, adopted attack frequency as the sole measure of PNES outcome. 50 In this context, the use of a prospective cohort such as in the present investigation has been rarely done among follow‐up studies that used the time of diagnosis as the entry point.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases—Results at 1‐year follow‐up examinations

et al. 2023

View full text Add to dashboard Cite

Objective: The primary purpose of this prospective multicenter study was to examine clinical and demographic feature differences according to the diagnostic level of psychogenic nonepileptic seizures (PNES) and then clarify whether prognosis may also differ accordingly.Methods: Two hundred forty-two consecutive patients strongly suspected of having PNES attacks were invited to participate, of whom 52 did not consent or contact was lost. At the 1-year follow-up examination, PNES diagnosis was reconsidered in nine patients. In 96 patients, the diagnostic level remained the same (P-group), with that in 43 considered to be clinically established (CEgroup) and in 42 documented (D-group). The Qolie-10 and NDDI-E questionnaires were examined at both the study entry and the follow-up examination.Results: Multiple regression analysis of quality of life (QoL) score (n = 173; R 2 = 0.374; F = 7.349; P < 0.001) revealed NDDI-E score (t = −6.402; P < 0.001), age of PNES onset (t = −3.026; P = 0.003), and ethnic minority status (t = 3.068; P = 0.003) as significant contributors. At entry, the P-group showed the lowest PNES attack frequency (P < 0.000), the lowest rate of antiseizure, antidepressant, and antipsychotic medication (P < 0.000; P = 0.031; P = 0.013, respectively), and the lowest proportion of psychosis (P = 0.046). At follow-up, PNES attack frequency (P < 0.000), number of admittances to emergency room (P < 0.000), and scores for QoL (P < 0.000) as well as depression (P = 0.004) were found to be significantly improved together with other collateral indicators, such as rate of antiseizure medication prescription (P = 0.001) and psychiatric symptoms (P = 0.03).Multiple regression analysis of a sample limited to patients with intellectual disability (ID) (n = 44; R 2 = 0.366; F = 4.493; P = 0.002) revealed continued psychotherapy at follow-up (t = 2.610, P = 0.013) and successful reduction in antiseizure medication (t = 2.868; P = 0.007) as positively related with improved QoL.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases—Results at 1‐year follow‐up examinations

et al. 2023

View full text Add to dashboard Cite

show abstract

“… 75 Quality of life of people with FND-seizures was significantly associated with dissociative symptoms in two studies. 81 , 115 Both measured quality of life using the 31-item Quality of Life in Epilepsy Inventory (QOLIE-31). 116 Individuals with higher degrees of dissociation measured by the DES had worse QOLIE-31 scores than those with lower DES scores.…”

Section: Resultsmentioning

confidence: 99%

“…51,78,80,87,93,103 Quality of life in people with FND-seizures was also reportedly affected by degree of dissociation, even after controlling for a number of other factors. 81,115 Other studies observed varying severity of presentation with level of dissociation in general FND populations. The concerning link between dissociative symptoms and suicide has been established previously in psychiatric samples.…”

Section: Clinical Features Associated With Dissociation In Fndmentioning

confidence: 99%

Dissociation and its biological and clinical associations in functional neurological disorder: systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Background Studies have reported elevated rates of dissociative symptoms and comorbid dissociative disorders in functional neurological disorder (FND); however, a comprehensive review is lacking. Aims To systematically review the severity of dissociative symptoms and prevalence of comorbid dissociative disorders in FND and summarise their biological and clinical associations. Method We searched Embase, PsycInfo and MEDLINE up to June 2021, combining terms for FND and dissociation. Studies were eligible if reporting dissociative symptom scores or rates of comorbid dissociative disorder in FND samples. Risk of bias was appraised using modified Newcastle–Ottawa criteria. The findings were synthesised qualitatively and dissociative symptom scores were included in a meta-analysis (PROSPERO CRD42020173263). Results Seventy-five studies were eligible (FND n = 3940; control n = 3073), most commonly prospective case–control studies (k = 54). Dissociative disorders were frequently comorbid in FND. Psychoform dissociation was elevated in FND compared with healthy (g = 0.90, 95% CI 0.66–1.14, I2 = 70%) and neurological controls (g = 0.56, 95% CI 0.19–0.92, I2 = 67%). Greater psychoform dissociation was observed in FND samples with seizure symptoms versus healthy controls (g = 0.94, 95% CI 0.65–1.22, I2 = 42%) and FND samples with motor symptoms (g = 0.40, 95% CI −0.18 to 1.00, I2 = 54%). Somatoform dissociation was elevated in FND versus healthy controls (g = 1.80, 95% CI 1.25–2.34, I2 = 75%). Dissociation in FND was associated with more severe functional symptoms, worse quality of life and brain alterations. Conclusions Our findings highlight the potential clinical utility of assessing patients with FND for dissociative symptomatology. However, fewer studies investigated FND samples with motor symptoms and heterogeneity between studies and risk of bias were high. Rigorous investigation of the prevalence, features and mechanistic relevance of dissociation in FND is needed.

show abstract

“…Other similar studies have provided the same evidence (of a poorer QOL in people with FS compared with that in patients with epilepsy) [62] . Depression (the strongest correlate), dissociation, somatic symptoms, impaired cognition, and family dysfunction are often negatively associated with health-related QOL in people with FS [41] , [58] , [63] .…”

Section: Quality Of Lifementioning

confidence: 99%