Explanation for the selective crystallization from inosine solutions using mid-frequency Raman difference spectra analysis

Abstract

The experimental phenomena that amorphous inosine (IR), α-IR, and IR dihydrate can form from IR aqueous solution and β-IR can crystallize from IR 70 vol% DMSO aqueous solution were explained using mid-frequency Raman difference spectra analysis.

Evaporative Crystallization of Simvastatin from Different Solutions Using Mid-Frequency Raman Difference Spectra Explanations

“…Mid-frequency Raman difference spectra analysis can reveal the selective crystallization from solutions by determining the degree of similarity of the short-range orders between the assemblies of small organic molecules in solutions and their solid phases, which would shed light on the crystallization product prediction and have potential applications in the industrial process. As reported in our previous work, 25 the selective crystallization of inosine solutions has been well explained by using mid-frequency Raman difference spectra analysis. However, as a new analysis method, more application examples are needed to verify its effectiveness, and continuously improve and optimize it.…”

Crystallization Selectivity of Ribavirin Solution and Amorphous Phase

“…The flexible part endows ribavirin with rich conformational potential and its many hydrogen-bonding units induce complex intermolecular interactions. These factors favor the formation of polymorphs and amorphous phases, as is the case for guanosine and inosine [11].…”

“…The control of molecular polymorphisms has been studied thoroughly in the laboratory and in industrial production, and selective crystallization processes are observed in many different systems [7,8], such as solution crystallization, melt crystallization, amorphous phase recrystallization, solvate desolvation, and evaporative crystallization [9,10]. For example, it is easy to obtain the metastable inosine α form from aqueous solution or the stable inosine β form from dimethylsulfoxide (DMSO) solution [11]. Amorphous guanine Molecules 2023, 28, 6320 2 of 16 has a tendency to recrystallize into the metastable anhydrous guanine β form in biominerals and in the laboratory [12,13], and amorphous calcium carbonate can have different short-range orders, such as calcite or vaterite [14].…”

“…Standard analysis techniques that relate to monomer assembly and crystals i FTIR, Raman, NMR, and neutron scattering. However, they are inadequate in corr all the related phases at the same time and establishing similarities among these p Our group has proposed mid-frequency Raman difference spectroscopy (MFR solve this problem and has established phase relationships to explain the selectiv tallization behaviors of inosine and simvastatin [11,19]. It is still necessary, howe test the power of MFRDS and identify new selective crystallization process well-researched molecules based on MFRDS results.…”

Explanation and prediction of the selective crystallization of boscalid by mid-frequency Raman difference spectroscopy analysis

“…The smaller the a.d. and s.d., the higher degree of similarity between the two phases. 17 MFRDS analysis shed light on the prediction of the crystallization products and has potential applications in the industrial process. More models are needed to refine the method.…”