Explainable AI for CHO cell culture media optimization and prediction of critical quality attribute
Neelesh Gangwar,
Keerthiveena Balraj,
Anurag S. Rathore
Abstract:Cell culture media play a critical role in cell growth and propagation by providing a substrate; media components can also modulate the critical quality attributes (CQAs). However, the inherent complexity of the cell culture media makes unraveling the impact of the various media components on cell growth and CQAs non-trivial. In this study, we demonstrate an end-to-end machine learning framework for media component selection and prediction of CQAs. The preliminary dataset for feature selection was generated by… Show more
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