Expert’s comment concerning Grand Rounds case entitled “Synovial sarcoma of the spine: a case involving paraspinal muscle with extensive calcification and the surgical consideration in treatment” (by Junhyung Kim, Sun-Ho Lee, Yoon-La Choi, Go Eun Bae, Eun-Sang Kim, Whan Eoh)

Ashford, Robert U.

doi:10.1007/s00586-013-2856-8

Cited by 1 publication

(3 citation statements)

References 21 publications

(23 reference statements)

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“…Management of spinal SS should follow the instruction of a multidisciplinary team, and surgical resection serves as the first choice, if wide excision with clear margins is possible [ 28 – 31 ]. Subtotal resection of the tumour might be followed shortly by a local recurrence [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Adjuvant therapies are beneficial for large, deep and high-grade STSs [ 28 ]. Six patients with an advanced tumour stage and relatively stable general status had chemotherapy and local radiotherapy following the operation.…”

Section: Discussionmentioning

confidence: 99%

“…Naphade et al [ 37 ] reported a case of cervical SS where the tumour was completely excised without adjuvant treatment, and no signs of local recurrence or metastasis were detected at 6 months after surgery. There is no consensus about the role of adjuvant and preoperative chemotherapy in SS [ 28 ]. A previous study demonstrated that SS tended to have higher chemosensitivity compared to other STSs [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Surgical management and outcome of synovial sarcoma in the spine

et al. 2018

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BackgroundSynovial sarcoma (SS) is a soft tissue sarcoma that rarely occurs in the spine, and a minimal number of cases have been reported in the literature. Spinal SS is challenging in diagnosis and treatment and has a poor prognosis. The aim of this study was to summarize and analyse the clinical features and outcomes of patients with spinal SS.MethodsA total of 16 cases of patients with spinal SS admitted to our institution were reviewed retrospectively. General information, radiological findings and treatment strategies were collected. These patients were followed up regarding their continuing treatment, local or distant recurrence and survival.ResultsSpinal SS patients in this series ranged in age from 12 to 68 years (median, 33). Four en bloc resections and 12 piecemeal resections were performed. Improved Frankel (P = 0.002), visual analogue scale (P = 0.002) and Karnofsky Performance Status (P = 0.002) scores were seen postoperatively. The mean follow-up period was 35.9 ± 23.5 (median 31.5, range 4–87) months, with four local recurrences and three distant metastases detected. Eight patients (50.0%) died of disease by the last follow-up. The 1-, 3- and 5-year overall survival rates were 87.5%, 61.4% and 40.9%, respectively. Preoperative chemotherapy was used in three patients to facilitate surgical resection, and adjuvant chemotherapy and radiotherapy were used in six patients.ConclusionsSpinal SS has a relatively high risk of local recurrence and distant metastasis. Surgical intervention can improve the neurological function and relieve pain in these patients. En bloc excision is an effective treatment strategy to improve survival and prevent local recurrence. Management of spinal SS should be under the instruction of a multidisciplinary team.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%