Expert Report on Immune Thrombocytopenia: Current Diagnostics and Treatment – Recommendations from an Expert Group from Austria, Germany, and Switzerland

Abstract

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Risk‐based and individualised management of bleeding and thrombotic events in adults with primary immune thrombocytopenia (ITP)

“…60 The impact of menorrhagia on patients' QoL was assessed using data from seven studies and indicated that menorrhagia had a negative influence on a patients' QoL, particularly F I G U R E 1 Key aspects of patient education in bleeding and thrombotic risk. 9,16,83 patients with a low PC. 74 In the iWISH study on patient perception, menorrhagia was rated as one of the most severe symptoms of ITP by 83% of surveyed patients who experienced it at diagnosis and by 62%…”

“…13 This risk of thromboembolism is increased in the presence of certain patient characteristics, such as older age, certain ITP treatments and even aspects of the disease itself. [14][15][16] Thrombotic events will also require initiation of anticoagulant and/or antiplatelet therapy and this can be challenging in patients with low PC. This review will discuss the risks of both bleeding and thrombotic events in adult ITP patients, as well as the aspects of ITP that specifically impact on women's health and quality of life, which are of particular concern due to haemorrhagic and thrombotic complications.…”

“…Ensuring that patients are informed and aware of the lifestyle risks, disease history, signs and symptoms of either event should also form a key part of disease management. 16…”

Clinical significance of antinuclear antibodies in primary immune thrombocytopenia

“…2 Huge variations exist across national guidelines from the recommendation to not test systematically every ITP for ANA (e.g. the recent German, Austrian and Swiss expert guidelines), 3 to systematic dosage (e.g. 2017 French guidelines).…”

Identification of an Unmet Medical Need – Height of Depression, Hypersomnia and Sleep Apnea Positively Correlate with the Level of Fatigue in Patients with Immune Thrombocytopenia

“…Introduction Immune thrombocytopenia (ITP) is a rare chronic disease, frequently accompanied by fatigue, which is an important comorbidity associated with this disease 1 . Patients experience difficulties to manage their daily activities and a reduction in their overall quality of life (QoL) 2 .…”