Expert position paper on air pollution and cardiovascular disease

Newby, David E.; Mannucci, Pier Mannuccio; Tell, Grethe S.; Baccarelli, Andrea; Brook, Robert D.; Donaldson, Ken; Forastiére, Francesco; Franchini, Massimo; Franco, Oscar H.; Graham, Ian; Hoek, Gerard; Hoffmann, Barbara; Hoylaerts, Marc; Künzli, Nino; Mills, Nicholas L; Pekkanen, Juha; Peters, Annette; Piepoli, Massimo F; Rajagopalan, Sanjay; Storey, Robert F.

doi:10.1093/eurheartj/ehu458

Cited by 675 publications

(438 citation statements)

References 97 publications

Supporting

Mentioning

414

Contrasting

Unclassified

Order By: Relevance

“…We found that high (>20.9 μg/m 3 ) as compared with low (<14.3 μg/m 3 ) residential NO 2 exposure was associated with 17% increased risk of incident MI, in agreement with Roswall et al, and 39% increased risk for recurrent MI, which is a novel finding. The findings in this cohort agree with previous evidence showing that exposure to outdoor air pollution increases risk of CVD morbidity and mortality 12, 13, 14, 39…”

Section: Discussionsupporting

confidence: 92%

“…In 2015, it was estimated that exposure to air pollution, in terms of fine particulate matter, was responsible for 4.2 million deaths, representing 7.6% of total global deaths, with a majority of them caused by cardio‐ and cerebrovascular disease 11. Exposure to outdoor air pollution is an established risk factor for CVD morbidity and mortality, including MI 12, 13, 14. Inflammation and oxidative stress are suggested as principal underlying mechanisms for the detrimental effects of air pollution on the cardiovascular system 15, 16…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study

Kubesch

Jørgensen

Hoffmann

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

BackgroundPhysical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to traffic‐related air pollution.Methods and ResultsA group of 57 053 participants (50–65 years of age) from the Danish Diet, Cancer, and Health cohort reported physical activity at baseline (1993–1997) and were linked to registry data on hospital contacts and out‐of‐hospital deaths caused by MI, until December 2015. Nitrogen dioxide levels were estimated at participants’ baseline residences. We used Cox regressions to associate participation in sports, cycling, walking, and gardening with incident and recurrent MI, and tested for interaction by nitrogen dioxide. Of 50 635 participants without MI at baseline, 2936 developed incident MI, and of 1233 participants with MI before baseline, 324 had recurring MI during follow‐up. Mean nitrogen dioxide concentration was 18.7 μg/m3 at baseline (1993–1997). We found inverse statistically significant associations between participation in sports (hazard ratio; 95% confidence interval: 0.85; 0.79–0.92), cycling (0.91; 0.84–0.98), gardening (0.87; 0.80–0.95), and incident MI, while the association with walking was statistically nonsignificant (0.95; 0.83–1.08). Recurrent MI was statistically nonsignificantly inversely associated with cycling (0.80; 0.63–1.02), walking (0.82, 0.57–1.16), and gardening (0.91; 0.71–1.18), and positively with sports (1.06; 0.83–1.35). There was no effect modification of the associations between physical activity and MI by nitrogen dioxide.ConclusionsBenefits of physical activity on both the incidence and the recurrence of MI are not reduced by exposure to high levels of air pollution.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study

Kubesch

Jørgensen

Hoffmann

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

show abstract

“…Increasing amounts of data suggest exposure to PM 2.5 increases the risk of cardiovascular deaths and diseases in the short and long terms 6, 7, 8, 9, 10. It also has been suggested that the long‐term effects of PM 2.5 have a greater impact on cardiovascular mortality than the short‐term effects 4, 5…”

mentioning

confidence: 99%

Cardiovascular Effects of Long‐Term Exposure to Air Pollution: A Population‐Based Study With 900 845 Person‐Years of Follow‐up

Kim

et al. 2017

JAHA

146

View full text Add to dashboard Cite

BackgroundStudies have shown that long‐term exposure to air pollution such as fine particulate matter (≤2.5 μm in aerodynamic diameter [PM 2.5]) increases the risk of all‐cause and cardiovascular mortality. To date, however, there are limited data on the impact of air pollution on specific cardiovascular diseases. This study aimed to evaluate cardiovascular effects of long‐term exposure to air pollution among residents of Seoul, Korea.Methods and ResultsHealthy participants with no previous history of cardiovascular disease were evaluated between 2007 and 2013. Exposure to air pollutants was estimated by linking the location of outdoor monitors to the ZIP code of each participant's residence. Crude and adjusted analyses were performed using Cox regression models to evaluate the risk for composite cardiovascular events including cardiovascular mortality, acute myocardial infarction, congestive heart failure, and stroke. A total of 136 094 participants were followed for a median of 7.0 years (900 845 person‐years). The risk of major cardiovascular events increased with higher mean concentrations of PM 2.5 in a linear relationship, with a hazard ratio of 1.36 (95% confidence interval, 1.29–1.43) per 1 μg/m3 PM 2.5. Other pollutants including PM 2.5–10 of CO, SO 2, and NO 2, but not O3, were significantly associated with increased risk of cardiovascular events. The burden from air pollution was comparable to that from hypertension and diabetes mellitus.ConclusionsThis large‐scale population‐based study demonstrated that long‐term exposure to air pollution including PM 2.5 increases the risk of major cardiovascular disease and mortality. Air pollution should be considered an important modifiable environmental cardiovascular risk factor.

show abstract

“…Notou-se que diversas condições importantes, como infarto agudo do miocárdio, acidente vascular cerebral, fibrilação atrial e insuficiência cardíaca, não apresentaram sequer um registro relevante com dados específicos à cidade de Vitória. Muitos desses eventos cardiovasculares possuem relação importante com a poluição ambiental 36 , e a falta de estudos sobre esses tópicos limita grandemente a capacidade de sintetizar a evidência acerca da epidemiologia das doenças cardiovasculares em Vitória. Quanto à RS2, deve-se salientar que a quantidade de artigos incluídos, ainda que de acordo com os propósitos deste relatório, é consideravelmente menor do que o habitual encontrado em revisões sistemáticas, limitando a capacidade de síntese e análise de dados comum às metanálises.…”

Section: Discussionunclassified

Revisão Sistemática Sobre a Epidemiologia Das Doenças Cardiovasculares E Respiratórias E Suas Associações Com a Poluição Do Ar Em Vitória/Es

Tufik¹,

Kim²,

Tempaku³

et al. 2017

Clin. Biomed. Res.

View full text Add to dashboard Cite

show abstract

Expert position paper on air pollution and cardiovascular disease

Cited by 675 publications

References 97 publications

Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study

Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study

Cardiovascular Effects of Long‐Term Exposure to Air Pollution: A Population‐Based Study With 900 845 Person‐Years of Follow‐up

Revisão Sistemática Sobre a Epidemiologia Das Doenças Cardiovasculares E Respiratórias E Suas Associações Com a Poluição Do Ar Em Vitória/Es

Contact Info

Product

Resources

About