Despite being an easily preventable disease, as more than 85% of the cases are caused by smoking, lung cancer has been the leading cause of cancer death worldwide since 1987. Especially in developing countries, the incidence of lung cancer is increasing drastically due to the increased use of tobacco products. Many Western countries have managed to control the prevalence of smoking leading to a reduction in lung cancer incidence. However, with a combined population of approximately 360 million in the Middle East and North African (MENA) region, up to 46% of the populations continue to smoke and more people are picking up the deadly habit. The challenges in the MENA countries are not just related to the increasing rate of incidence which reflects a failure in primary prevention, but also in the diagnosis and management of the affected patients; especially in lieu of recent advances and availability of more "expensive" management options. In this editorial, we present the status of lung cancer in terms of burden, management patterns, available resources, and challenges in the MENA region. For the purpose of this paper, the MENA region covers countries in the Arab League including the Gulf Cooperation Council (GCC) countries