One of the key ingredients needed to extract quantitative information on neutrino absolute mass scale from the possible measurement of the neutrinoless double-beta (0νββ) decay half-lives is the nuclear matrix element (NME) characterizing such transitions. NMEs are not physical observables and can only be deduced by theoretical calculations. However, since the atomic nuclei involved in the decay are many-body systems, only approximated values are available to date. In addition, the value of the coupling constants to be used for the weak interaction vertices is still an open question, which introduces a further indetermination in the calculations of NMEs. Several experimental approaches were developed in the years with the aim of providing useful information to further constrain the theory. Here we give an overview of the role of charge exchange reactions in this scenario, focusing on second-order processes, namely the double charge exchange (DCE) reactions.