Experiments on N-P Scattering With 260 Mev Neutrons

Kelly, E.L.; Leith, C. E.; Segrè, E.; Wiegand, C.

doi:10.2172/910353

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the stoichiometry of the 50-kDa and 60-kDa subunits of CaM kinase I1 appears to vary in different regions of the brain, e. g. forebrain versus cerebellum [49, 501. Recent studies also suggest that the subunit composition of CaM kinase I1 is altered during neuronal differentiation from predominantly 60-kDa subunit in neonates to a holoenzyme with an increased content of the 50-kDa subunit in the adult forebrain [51] (Kelly et al, unpublished results). Taken together, such data point to the presence of isoenzymic forms, which are differentially expressed in mammalian tissues.…”

Section: Discussionmentioning

confidence: 96%

Calmodulin‐dependent multifunctional protein kinase

Shenolikar¹,

Lickteig²,

Hardie

et al. 1986

European Journal of Biochemistry

View full text Add to dashboard Cite

Calcium/calmodulin-dependent multifunctional protein kinases, extensively purified from rat brain (with apparent molecular mass 640 kDa), rabbit liver (300 kDa) and rabbit skeletal muscle (700 kDa), were analysed for their structural, immunological, and enzymatic properties. The immunological cross-reactivity with affinitypurified polyclonal antibodies to the 50-kDa catalytic subunit of the brain calmodulin-dependent protein kinase confirmed the presence of common antigenic determinants in all subunits of the protein kinases. One-dimensional phosphopeptide patterns, obtained by digestion of the autophosphorylated protein kinases with S. aureus V8 protease, and two-dimensional fingerprints of the '251-labelled proteins digested with a combination of trypsin and chymotrypsin, revealed a close similarity between the two subunits (51 kDa and 53 kDa) of the liver enzyme. Similar identity was observed between the 56-kDa and/or 58-kDa polypeptides of the skeletal muscle calmodulindependent protein kinase. The data suggest that the subunits of the liver and muscle protein kinases may be derived by partial proteolysis or by autophosphorylation. The peptide patterns for the 50-kDa and 60-kDa subunits of the brain enzyme confirmed that the two catalytic subunits represented distinct protein products. The comparison of the phosphopeptide maps and the two-dimensional peptide fingerprints, indicated considerable structural homology among the 50-kDa and 60-kDa subunits of the brain calmodulin-dependent protein kinase and the liver and muscle polypeptides. However, a significant number of unique peptides in the liver 51-kDa subunit, skeletal muscle 56-kDa, and the brain 50-kDa and 60-kDa polypeptides were observed and suggest the existence of isoenzyme forms. All calmodulin-dependent protein kinases rapidly phosphorylated synapsin I with a stoichiometry of 3 -5 mol phosphate/mol protein. The two-dimensional separation of phosphopeptides obtained by tryptic/chymotryptic digestion of 32P-labelled synapsin I indicated that the same peptides were phosphorylated by all the calmodulin-dependent protein kinases. Such data represent the first structural and immunological comparison of the liver calmodulin-dependent protein kinase with the enzymes isolated from brain and skeletal muscle. The findings indicate the presence of a family of highly conserved calmodulin-dependent multifunctional protein kinases, with similar structural, immunological and enzymatic properties. The individual catalytic subunits appear to represent the expression of distinct protein products or isoenzymes which are selectively expressed in mammalian tissues.Protein phosphorylation is widely recognised as a major mechanism by which hormones elicit control of cellular processes leading to a variety of physiological responses [l]. The modification of cellular proteins is mediated by specific protein kinases following changes in the intracellular concentration of selected effector molecules or 'second messengers'. In this regard the ubiquitous presence of cyclic-AMP...

show abstract

Section: Discussionmentioning

confidence: 96%

Calmodulin‐dependent multifunctional protein kinase

Shenolikar¹,

Lickteig²,

Hardie

et al. 1986

European Journal of Biochemistry

View full text Add to dashboard Cite

show abstract

“…158 Fraenkel's initial thinking on this had been influenced by Marxist and socialist legal thought, as well as by the work of his former colleague Neumann, with whom he had set up a law practice in the late 1920s. 159 But the original German work refuted what he saw as some of their excessive conclusions:…”

Section: A Against the Economic Constitution: Juridical Modernism And...mentioning

confidence: 99%

Constitution-Making as a Technique of International Law: Reconsidering the Post-war Inheritance

Saunders

2023

Am. j. int. law

View full text Add to dashboard Cite

Over the last three decades, international lawyers and institutions have come to understand constitution-making as an accepted technique of international law and a means of delivering peace and security. In defending this technique from its critics, scholars have drawn on a particular tradition of constitution-making developed in the postwar period and in respect of the Allied occupations of Germany and Japan. That tradition understands constitutionalism as a lawful form of international action, allowing for temporary forms of international rule, and juridically distinct from material concerns. I explore the building of this tradition through the work of three legal scholars: Ernst Fraenkel, Quincy Wright, and Carl Friedrich.I argue that reimagining constitutionalism for the coming decades requires rethinking this separation between the juridical and the material, as well as asking what constitutionalism demands of the laws governing the global economy.

show abstract

“…258 Secondly, as M68 demonstrates, Parliament is likely to go to significant lengths in attempting to 'judge-proof' decisions, or to salvage programs which have been wounded by judicial intervention. Thirdly, constant litigation fatigues administrators, 259 lowering morale, job satisfaction, performance, and productivity. Finally, a degree of economic waste accrues from the persistent 'administrative risk' created by the possibility that programs will be unexpectedly altered by judicial review.…”

Section: Federal Law Reviewmentioning

confidence: 99%

Tiptoeing through the Tripwires: Recent Developments in Jurisdictional Error

Moss

2016

Federal Law Review

View full text Add to dashboard Cite

Australian administrative law's continuing emphasis on the concept of jurisdictional error is increasingly unique amongst common law jurisdictions. This paper argues that recent developments in Australian jurisprudence have provided little guidance for administrative decision-makers, who are left ‘tiptoeing through the tripwires’ of judicial review. Combining a detailed analysis of primary decisions, academic publications and historical scholarship, this paper suggests that this lack of guidance is the result of a widespread judicial reluctance to engage with either the guidance or educative roles of judicial review. As this paper demonstrates, failure to do so encourages uncertainty, unpredictability and a general lack of clarity which inhibits judicial review's ability to guide decision-makers and contribute to the maintenance of effective governance, administrative justice, and the rule of law in Australia. Particular attention is given to the decisions of Minister for Immigration and Citizenship v Li, Plaintiff M61/2010E v Commonwealth, and NBMZ v Minister for Immigration and Border Protection, which together encapsulate many of the most problematic aspects of recent jurisprudence. To avoid these consequences, this paper calls on senior judges and commentators to articulate a clearer framework which will be applied to guide the future development of the doctrine of jurisdictional error.

show abstract

Experiments on N-P Scattering With 260 Mev Neutrons

Cited by 4 publications

References 0 publications

Calmodulin‐dependent multifunctional protein kinase

Calmodulin‐dependent multifunctional protein kinase

Constitution-Making as a Technique of International Law: Reconsidering the Post-war Inheritance

Tiptoeing through the Tripwires: Recent Developments in Jurisdictional Error

Contact Info

Product

Resources

About