Experiments on a new Clotting Factor (Factor VII)

Koller, F; Loeliger, A; Duckert, F

doi:10.1159/000203899

Cited by 303 publications

(84 citation statements)

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“…Our finding that thrombolysis with streptokinase totally or partially clears occluded veins in 67%// of cases compared with 10%' of heparin-treated patients corresponds with those of others in studies of fewer patients (Browse et al, 1968;Kakkar et al, 1969 a;Robertson et al, 1970;Jacobsen, 1973 Schmitt (1975), loose thrombi are more recent than adherent ones a good prognosis can never be made on the evidence of the phlebogram. It can merely be established that proximal veins, important for venous return, are more often reopened than distal ones, possibly because the occlusions are usually more recent.…”

Section: Discussionsupporting

confidence: 85%

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Treatment of deep vein thrombosis with streptokinase.

Duckert¹,

Müller²,

Nyman³

et al. 1975

BMJ

117

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145 patients with acute or subacute deep vein thrombosis confirmed by phlebography were treated with streptokinase. During the same period 42 patients considered unfit for thrombolytic therapy were treated with herapin and oral anticoagulants. The results, assessed by repeat phlebography, in 93 of the patients treated with streptokinase were compared with those in the 42 patients treated with heparin. The age, sex, and severity of occlusion were roughly similar in both groups. Streptokinase treatment was successful in 420,, partially successful in 25%, and unsuccessful in 32% of the 93 patients compared with none, 10%, and 880/ respectively in the 42 patients treated with heparin.Streptokinase was more effective when the thrombus was in proximal rather than calf veins. Thrombi of more than six days old were readily lysed. Plasma fibrinogen levels were below 0 8 g/l (80 mg/100 ml) in nearly all patients successfully treated. The incidence of pulmonary embolism was no greater with streptokinase than with heparin treatment. Only prolonged follow-up would show whether thrombolytic treatment would be effective in preventing late complications of deep vein thrombosis such as chronic venous insufficiency.

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Section: Discussionsupporting

confidence: 85%

“…The coagulation factors II, VII (Koller et al, 1951), and X (Bachmann et al, 1958) were assayed by previously described methods. Quick prothrombin times under heparin infusion were measured by the method of Seiler et al (1970).…”

Section: Laboratory Testsmentioning

confidence: 99%

Treatment of deep vein thrombosis with streptokinase.

Duckert¹,

Müller²,

Nyman³

et al. 1975

BMJ

117

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show abstract

“…The so-called antihaemophilic globulin, associated with the fibrinogen fraction of normal plasma is probably also necessary because haemophilic blood, which lacks this factor, shows a great delay in prothrombin conversion. A third factor, called 'factor VII' (Koller, Loeliger & Duckert, 1951) may also be required. This substance which has been called 'convertin' (Owren, 1950), 'co-thromboplastin' , 'serum prothrombin conversion accelerator' (de Vries, Alexander & Goldstein, 1949) is apparently needed for the reaction of brain extracts with prothrombin (Owren, 1950;Koller et al 1951) and might reasonably be expected to be necessary for the action of the blood thromboplastin system.…”

mentioning

confidence: 99%

The formation of thromboplastin in human blood

Biggs¹,

Douglas²,

Macfarlane³

1953

The Journal of Physiology

127

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“…(16). It is well known that Factor VII will accelerate the coagulation of shed blood in vitro (17)(18)(19) and several investigators have demonstrated a temporary rise in the convertin complex during pregnancy and in the puerperium-a period when venous thrombosis and pulmonary embolism are not uncommon (20)(21)(22)(23). However, no causal relationship has yet been demonstrated between increased levels of circulating Factor VII and the deposition of in vivo thrombi in man.…”

Section: Discussionmentioning

confidence: 99%