Experiments, Correlation, and Modeling of Curcumin Solubility in Subcritical Water (Water/Ethanol)

Mohammadi, Sakineh; Asl, Ali Haghighi; Mottahedin, Pouya

doi:10.1007/s10337-020-03946-4

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…The solubility of the curcumin molecule, which is biologically very active, was investigated under subcritical water conditions [ 50 ]. Experimental studies were performed under constant pressure at a temperature between 363 and 423 K using a range of 0–10% ( w / w ) ethanol as a co-solvent.…”

Section: Solubility In Subcritical Watermentioning

confidence: 99%

Solubility and Decomposition of Organic Compounds in Subcritical Water

et al. 2023

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In this article, studies on organic solubility and stability in subcritical water reported during the past 25 years have been reviewed. Data on the solubility and decomposition of organic compounds in subcritical water, a green solvent, are needed in environmental remediation, chemistry, chemical engineering, medicine, polymer, food, agriculture, and many other fields. For solubility studies, the experimental systems used to measure solubility, mathematical equations derived and applied for the modeling of the experimentally determined solubility data, and the correlation between the predicated and experimental data have been summarized and discussed. This paper also reviewed organic decomposition under subcritical water conditions. In general, the solubility of organics is significantly enhanced with increasing water temperature. Likewise, the percentage of organic decomposition also increases with higher temperature.

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Section: Solubility In Subcritical Watermentioning

confidence: 99%

Solubility and Decomposition of Organic Compounds in Subcritical Water

et al. 2023

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“…Due to its generally 2D nanostructure, large specific surface area, and high cationic exchange capacity (CEC), Mt has shown great potential for being used in polymer nanocomposites, wastewater treatment, drug delivery systems, and tissue engineering. , However, the use of Mt in water-based polymer nanocomposites (polyethylene glycol, polyurethane, etc. ), hydrophobic drugs (curcumin, 5-fluorouracil, etc. ), and proteins has been limited and for these applications, it is essential to understand the interaction mechanisms operating between Mt and dispersing solvents.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 However, the use of Mt in water-based polymer nanocomposites (polyethylene glycol, 8 polyurethane, 9 etc. ), hydrophobic drugs (curcumin, 10 5fluorouracil, 11 etc. ), and proteins has been limited and for these applications, it is essential to understand the interaction mechanisms operating between Mt and dispersing solvents.…”

Section: ■ Introductionmentioning

confidence: 99%

Tunable Colloidal Properties of Lauramidopropyl Betaine and Li Co-modified Montmorillonite in Ethanol/Water

Liu,

Gates,

Yang

et al. 2024

Langmuir

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Montmorillonite (Mt) is a hydrophilic clay mineral with a generally high cationic exchange capacity and a remarkable swellability in water. Yet the application of Mt in cosmetics, paints, polymer nanocomposites, drug delivery systems, and tissue engineering are limited due to its unfavorable swelling and dispersion in alcohol/water mixtures. Improving the swellability and dispersibility of Mt in mixtures of ethanol and water remains challenging. Here, we showed that the swellability and dispersibility of Mt in ethanol/water could be significantly enhanced when lithium-Mt (Li-Mt) was intercalated by zwitterionic surfactant lauramidopropyl betaine (LPB). The binding mechanism of the LPB intercalate to Li-Mt originated from a combination of van der Waals forces, ion-dipole interaction, and electrostatic attraction. Due to the synergistic effect of Li + and LPB, the comodified Mt (LPB-Li-Mt) exhibited excellent swellability, dispersibility, and rheological properties. The structure, morphology, zeta potential, dispersibility, and gel-forming performance of LPB-Li-Mt can be modulated by the concentrations of ethanol in ethanol/water mixtures. When the ethanol concentration increased to 75% v/v ethanol solution, the free swelling of LPB-Li-Mt remained above 80%. The results from X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray photoemission spectrometry, and small-angle X-ray scattering confirmed the full exfoliation of LPB-Li-Mt at 75% (v/v) ethanol solution. The formation of a stable colloidal LPB-Li-Mt dispersion in a mixture of ethanol/water might be derived from the association between water molecules and the Li + , the hydrophobic interaction, and the iondipole of ethanol with the LPB molecules. The findings provide a guide for improving dispersion and swelling of Mt and modified ones in water-miscible organic solvents.

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