Experiments and Studies

Nahas, Gabriel G.; Desoize, B; Morishima, Akira; Hsu, Joseph

doi:10.1016/b978-0-08-023779-4.50038-0

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“…The growth of heart tissue of chicken embryo is inhibited by addition of n-alk(en)yl resorcinols at a concentration of 1 : 3000 (v/v) in the culture medium [24]. The presence of alkyl resorcinols inhibits blastogenesis of cultured human erythrocytes [25], causes errors in thymus lymphocyte chromosomes [26] and induces formation of rosettes of cells [27]. After oral administration of alkyl resorcinols to rats and chicken, the practical absence of gram-positive bacteria in cecum was shown [28]: The rabbits fed with resorcinols showed loss of weight, anorexia, lethargy and diarrhoea [29].…”

Section: Introductionmentioning

confidence: 99%

Permeability changes of erythrocytes and liposomes by 5-(n-alk(en)yl) resorcinols from rye

Kozubek

Demel

1980

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Summary 5-(n-Alk(en)yl) resorcinols can induce potassium release from liposomes and erythrocytes. The results suggest that 5-(n-pentyl)resorcinol can induce a specific permeability to protons as well as to potassium and other small molecules. The highest permeability changes were found in the presence of 5-(npentadecyl)resorcinol and alkenyl resorcinols. Orcin and resorcin were without effect. The size of permeant as investigated by turbidity measurements indicated that Ca 2÷ and Mg :÷ cannot pass through the alkyl resorcinol-modified membrane but can pass through the alkenyl resorcinol-modified membrane. It was observed that alkenyl resorcinol at a concentration of 15 #M induced not only potassium release but also lysis of erythrocytes.

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