Experiments and Correlations of the Solubility of <i>γ‐DL</i>‐Methionine in Binary Solvent Mixtures

Kongsamai, Peetikamol; Phoumixay, Channakhone; Wantha, Lek

doi:10.1002/ceat.201900642

Cited by 5 publications

(10 citation statements)

References 25 publications

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“…In this work, the solubility of halosulfuron-methyl was determined by an isothermal static technique. ,, Before each sample is taken out, the first thing to ensure is that the solute dissolution has reached a dynamic equilibrium. In order to achieve this goal, the overdose method was introduced into the experiment.…”

Section: Methodsmentioning

confidence: 99%

Equilibrium Solubility Investigation and Thermodynamic Computational Modeling of Halosulfuron-methyl in a Series of Cosolvent Mixtures at a Temperature Range of 278.15–323.15 K

et al. 2020

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Water as an auxiliary solvent is added to various alcohol solvents (methanol, ethanol, and isopropanol) and N,N-dimethylformamide (DMF) to form a variety of liquid mixtures, which are divided into different types according to different proportions. Starting from pure water, 0.1 mass fraction of organic solvents is added at a time until the ratio of organic solvent is 1. The abovementioned liquid mixtures are used as solvents to dissolve halosulfuron-methyl at 278.15–323.15 K under 101.2 kPa by means of the isothermal static technique. The experimental solubility of halosulfuron-methyl was calculated and validated by using three various computational models, i.e., Jouyban–Acree model, modified Apelblat–Jouyban–Acree model, and van’t Hoff–Jouyban–Acree model. Considering that there are many factors that change the experimental results, this experiment mainly selected temperature and water content as two factors as the main independent variables. From the point of view of temperature, it changes from a low value to a high value, so it is obvious that the solute mole fraction also follows its footsteps. Unlike the temperature, as the organic solvent is continuously diluted by water, the solute solubility changes in the opposite direction to the water content. By controlling the variable method to ensure that the above two variables remain unchanged, DMF has the best dispersion ability for all the selected solvents to dissolve halosulfuron-methyl. The solubility maximum of 2.542 × 10–3 at 323.15 K was found in pure DMF, and four systems followed the descending order as (DMF + water) > (ethanol + water) > (methanol + water) > (isopropanol + water). The largest relative average deviation and root-mean-square deviation values were 5.70 × 10–3 and 6.90 × 10–6, respectively. For drugs with poor water solubility and dissolution rate, measuring their solubility and understanding their dissolution properties could effectively help solve the problem of nonwetting and nondiffusion. The obtained equilibrium solubility and correlation parameters of halosulfuron-methyl in studied cosolvency systems could be favorable for the industrial production, recrystallization, and purification processes of API halosulfuron-methyl.

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Section: Methodsmentioning

confidence: 99%

Equilibrium Solubility Investigation and Thermodynamic Computational Modeling of Halosulfuron-methyl in a Series of Cosolvent Mixtures at a Temperature Range of 278.15–323.15 K

et al. 2020

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“…In this model, van’t Hoff equation (eq ) and Jouyban–Acree equation (eq ) are combined to correlate the relationship among temperature, , solvent composition, and solubility. It can be described as eq . ln nobreak0em.25em⁡ x = x 2 .25em nobreak0em0.25em⁢ ln false( x 1 false) 2 + x 3 .25em ln ( x 1 ) 3 + x 2 x 3 ∑ i = 0 N J i ( x 2 − x 3 ) i T ln nobreak0em.25em⁡ x = x 2 .25em nobreak0em0.25em⁢ ln ( a 1 + b 1 T ) + x 3 .25em nobreak0em0.25em⁢ ln ( a 2 + b 2 …”

Section: Theoretical Basismentioning

confidence: 99%

“…In this model, van’t Hoff equation (eq ) and Jouyban–Acree equation (eq ) are combined to correlate the relationship among temperature, , solvent composition, and solubility. It can be described as eq . where x 2 and x 3 are the molar composition of mixed solvent before adding solute; ( x 1 ) 2 and ( x 1 ) 3 are the solubility of solutes in 2-butanol and methanol; a 1 , b 1 , a 2 , and b 2 are derived from the van’t Hoff model fitting the solubility data of the solute in two pure solvents; N is the type of mixed solvent; T expresses the experimental temperature, J i is the model parameter, and in this system N = 2, x 3 = 1 – x 2 , this equation can be expressed as follows …”

Section: Theoretical Basismentioning

confidence: 99%

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Measurement and Correlation of the Solubility of Salbutamol in Ten Pure and Binary Mixed Organic Solvents from T = 283.15–328.15 K

Wen

Wang

2022

J. Chem. Eng. Data

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In this study, the gravimetric method was used to measure the solubility of salbutamol in ten pure and binary mixed organic solvents, including methanol, isobutanol, ethanol, isopropyl alcohol, 1-propanol, 1-butanol, 2-butanol, methyl acetate, ethyl acetate, acetone, and methanol + 2-butanol, in the range of 283.15−328.15 K at atmospheric pressure. The solubility curve showed an increasing trend with an increase in temperature. In addition, the modified Apelblat model, λh model, van't Hoff, van't Hoff−Jouyban−Acree, and Apelblat−Jouyban−Acree model were used to fit the experimental data, and the fitting results were satisfactory. Compared with other models, the Apelblat model showed the highest agreement with the experimental data. This work provides important data for the synthesis and purification of salbutamol.

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“…Also, Wantha et al. conducted several experiments for obtaining the DL ‐methionine polymorphs in aqueous solution 22–26. Though there are several reports available in the literature on the crystallization of DL ‐methionine polymorphs from aqueous solution and their structural evaluation under different experimental conditions, so far there is no explicit report available on the polymorphic separation of α‐ and β‐ polymorphs at the nucleation level.…”

Section: Introductionmentioning

confidence: 99%

Concomitant Polymorphism and Nucleation Control of DL‐Methionine Through Antisolvent Crystallization

Suresh

Srinivasan

2021

Chem Eng & Technol

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The concomitant polymorphism of the sulfur‐containing essential amino acid DL‐methionine was revealed, and α‐ and β‐polymorphic forms were separated from aqueous solution through antisolvent crystallization with ethanol as antisolvent. The addition of different volume fractions of ethanol into the mother solution reduces the solubility of DL‐methionine in double‐distilled water and in turn proportionately generates a range of supersaturation levels. This induces the nucleation of a stable β‐polymorph at low supersaturation levels, a mixture of α‐ and β‐ polymorphs at intermediate supersaturation levels, and a metastable α‐form at high supersaturation levels. Needle‐shaped α‐polymorphs and platy‐shaped β‐polymorphs were well distinguished through in‐situ optical microscopic analysis and their structural confirmation was done by X‐ray diffraction analysis.

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Experiments and Correlations of the Solubility of γ‐DL‐Methionine in Binary Solvent Mixtures

Cited by 5 publications

References 25 publications

Equilibrium Solubility Investigation and Thermodynamic Computational Modeling of Halosulfuron-methyl in a Series of Cosolvent Mixtures at a Temperature Range of 278.15–323.15 K

Equilibrium Solubility Investigation and Thermodynamic Computational Modeling of Halosulfuron-methyl in a Series of Cosolvent Mixtures at a Temperature Range of 278.15–323.15 K

Measurement and Correlation of the Solubility of Salbutamol in Ten Pure and Binary Mixed Organic Solvents from T = 283.15–328.15 K

Concomitant Polymorphism and Nucleation Control of DL‐Methionine Through Antisolvent Crystallization

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