Experimentelle Untersuchungen zur Photosensibilisierung der Haut durch pflanzliche Wirkstoffe

Phyto-Photo-Dermatitis

“…Obvious sweating was not found to be essential in the experiments detailed below. Following the production of bullae some forty-eight hours after the application of the undiluted juices of rue, wild parsnip, and figs in bright sunlight, Kuske (1938) began to investigate the photodynamic properties of a group of ketonic compounds known as furo-cumarins. Chemically pure compounds were obtained from oil of bergamot to produce bergapten, oxy-peucedoin from masterwort (Peucedanum ostruthium), and ficusin from figs, while others have been isolated from a number of essential oils as well as from dill and parsley.…”

“…Cultivated parsnips have been reported by Whittle, Hellier, and Lee (1946) (Klaber, 1942); common rue, Ruta graveolens (Oppenheim, 1932); the allied fraxinella, Dictamnus fraxinella (Baronovysky, 1929), and gasplant, D. albus (Cummer and Dexter, 1937); cow-parsnip, Heracleum sphondylium, and its cultivated relatives, H. giganteum, (Straton, 1912) and H. mantegazzianum (Miescher and Burckhardt, 1937;Kuske, 1938); figs, Ficus carica (Straton, 1912;Legge, 1921;Kitchevatz, 1934c;Behcet et al, 1939;Klaber, 1942) ; meadow grass, not identified specifically (Oppenheim, 1926;Hartmann and Briel, 1927;Corsi, 1933;Corson, 1935;Kitchevatz, 1936a); Persian or Tahitian lime (Sams, 1941); agrimony, Agrimonia eupatoria (O'Donovan, 1942).…”

Silicon photosensitizers in cancer therapy: Theoretical studies on novel 5‐methoxypsoralens

“…During 1930 to 1960, the identification of structure, synthesis, pigment‐stimulating properties, and photoactivity of psoralens was examined . Psoralens including 8‐methoxypsoralen (8‐MOP) and 5‐methoxypsoralen (5‐MOP, Bergapten) show ability to increase skin photosensitivity to high efficient treatment the hypopigmented skin of vitiligo, psoriasis, and other skin diseases . Psoralens are usually used to induce pigmentation in combination with long wave ultraviolet (UVA, 315‐400 nm) irradiation (PUVA therapy) .…”

Etude expérimentale de la phototoxicité de l’essence de Bergamote

“…L'origine de la phototoxicité de l'essence de bergamote a été, semble-t-il, décrite pour la première fois par Kuske [5] qui a isolé le bergaptène de l'es sence et a montré les propriétés photo-actives de ce psoralène. De nombreux travaux [9,10] ont ensuite précisé la phototoxicité de cette furocoumarine naturelle, mais on doit surtout à Marzulli et Maibach [8] d'avoir confirmé que de tous les psoralcnes contenus dans l'essence de bergamote, seul le bergaptène ou 5-méthoxypsoralène (5-MOP) était responsable des réactions cutanées.…”