Experimentelle Untersuchungen zur Frage der Photoallergie der Sulfonamide

Positive Skin Reaction Induced by 4,4′-Azoxybenzenedisulfonamide in Relationship to the Sulfanilamide Allergy

“…Group C was injected intracutaneously with 0.1 ml saline under the same conditions as a normal control. Sensitizations were performed in the absence of ultraviolet irradia tion, differing from the procedures of Schwarz and Speck [7] and Murata [5], Three weeks later, elicitation tests were carried out with 1% saline solutions of SA, 4-HABSA, 4-NSBSA and 4,4'-AZOBDSA in the A (SA-sensitized), B (4-HABSA-sensitized) and C (normal control) groups. All skin tests were graded 24 h after injec tions.…”

Photoallergy to “Jadit” with Photo Cross-Reactions to Derivatives of Sulfanilamide

“…Case 3 also shows an eczematous reaction to PHABSA without irradiation; such a cross reaction had been demonstrated in guinea-pigs by S c h w a r z a n d S pe c k (7,8) and by B u r c k h a r d t et al (2,3) upon patients photoallergic to sulfanilamide. The allergen formed in vivo following irradiation may be responsible for the eczematous reaction.…”

Role of <i>in viv</i><i>o</i>- and <i>in vitr</i><i>o</i>-formed Decomposition Products of Sulfanilamides and Phenothiazines in Photoallergy; Relationship of Spectrophotometric Findings to <i>in vivo</i> Reactions

“…One of the products, 4-hydroxylamino-6-chloro-benzenedisulfonamide, was obtained through in vitro synthesis and re sembled the product tested by Schwarz and Speck on guinea-pigs photoallergic to sulfanilamide (23). The other, 4-amino-G-chlorobenzene-disulfonamide, is the only known and isolated in vivo oxidation product of chlorothiazide.…”

“…Such products of irradiation may result from oxidation, reduction, dimerization, polymerization etc. Schwarz and Speck demonstrated in guinea-pig experiments that a particular oxidation product, p-hydroxylamino-bcnzencsulfonamidc (PHABSA) may be an eczematogen formed by the action of light upon sulfanilamide (23). Shinn el al.…”

“…11) photochemical action in which light provides energy for conversion of the drug into allergenic compounds (1,23) intensity of response inde pendent of allergen dosage (13) no specific wavelength need ed; the phenomenon may be initiated by any erythemaproducing irradiation light serves merely as a catalyst; the drug plays the prominent role (28) previous contact must be de monstrated; (however, once photoallergy occurs, the re action can be produced reg ularly within 24 h (9,11,20) occurs on areas both exposed and unexposed to light. 'Flare-ups' may follow photo patch testing (1,7) allergic cutaneous reactions: erythematous, urticarial, papular, eczematous (20).…”