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Two conceptions as to the r6lr of histamine in gastric secretion have been put forward. The fact that histamine is the sole gastric secretory excitant in dilute acid extracts of the pyloric niucosa was taken to indicate that histamine might be identical with "gastrin", the hormone instrumental in the gastric phase of secretion. As stressed by SACKS et al. (1932) the crucial question to he answered in this connection is whether the histamine concentration of the blood plasma riaes during the gastric phase. ~I A C~T O S H (1938), using the method of BARsouiv and G A D D u M , found that the histamine concmtration of the systemic blood was not significantly affected by the digestion of a meal. As discussed by MACINTOSH, there may have occurred in his experiments an increase in the histamine content of the plasma, which could not be detected in experinicnts with whole blood, and which gives values representing mainly the histamine content of the corpuscles. Experiments during the gastric phase with plasma, which normally contains very small aniounts of histamine as compared with the corpuscles, have not been published, as far as we know. The questions in regard to the r61e of histamine as a blood-born itgent active in the gastric phase have lost much of their bearing hy the recent work of KOMAROV (1941) and UvxSs et al. (MUXCH-PETERSEN, RONNOW and UVNAS 1944); these authors have isolated from the pyloric mucosa a protein-like substance free from histamine which on intravenous injection causes a profound secretion from the fundic glands.
Two conceptions as to the r6lr of histamine in gastric secretion have been put forward. The fact that histamine is the sole gastric secretory excitant in dilute acid extracts of the pyloric niucosa was taken to indicate that histamine might be identical with "gastrin", the hormone instrumental in the gastric phase of secretion. As stressed by SACKS et al. (1932) the crucial question to he answered in this connection is whether the histamine concentration of the blood plasma riaes during the gastric phase. ~I A C~T O S H (1938), using the method of BARsouiv and G A D D u M , found that the histamine concmtration of the systemic blood was not significantly affected by the digestion of a meal. As discussed by MACINTOSH, there may have occurred in his experiments an increase in the histamine content of the plasma, which could not be detected in experinicnts with whole blood, and which gives values representing mainly the histamine content of the corpuscles. Experiments during the gastric phase with plasma, which normally contains very small aniounts of histamine as compared with the corpuscles, have not been published, as far as we know. The questions in regard to the r61e of histamine as a blood-born itgent active in the gastric phase have lost much of their bearing hy the recent work of KOMAROV (1941) and UvxSs et al. (MUXCH-PETERSEN, RONNOW and UVNAS 1944); these authors have isolated from the pyloric mucosa a protein-like substance free from histamine which on intravenous injection causes a profound secretion from the fundic glands.
Summary. The effect of a vasodilating substance benzazolinchloride (Priscol) on the gastric secretion was studied in a Heidenhain pouch‐dog. It was found that: Priscol alone did not initiate secretion except in very high doses. but that it could enhance secretion already induced by histamine. This potentiating effect could be related to the strength of the existing stimulation. The higher the preceding secretion rate, the higher the effect of Priscol expressed as a coefficient of histamine equivalence. It was suggested that the action of histamine on the gastric glands is not due to its vasodilating property. The probability that the vasodilation causes an increased maximal secretory capacity was discussed. The esperiments were defrayed lip grants from the Medical Faculty of Uppsala.
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