Experimentelle Untersuchungen über die Regeneration der Aortenendothelzellen

Kunz, J; Schreiter, Bärbel; Schubert, B.; Voss, Klaus; Krieg, K

doi:10.1016/s0065-1281(78)80049-x

Cited by 22 publications

(2 citation statements)

References 8 publications

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“…3 Endothelial cell replication rates are elevated at these sites which are also prone to atherosclerotic lesion development. 21 If endothelial trauma is a primary initiator of atherogenesis, then the focal distribution of lesions may be linked to mechanisms of endothelial repair as well as injury. In this study, flow conditions in Zones I and II inhibited the repair of injury to endothelium.…”

Section: Discussionmentioning

confidence: 99%

Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits.

Langille¹,

Reidy²,

Kline³

1986

Arteriosclerosis

102

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The acute and chronic effects of flow disturbances on arterial endothelium were studied by locally constricting the diameter of the rabbit abdominal aorta by 62% + 2.4% (mean ± SE). This procedure produced a region of elevated shear stress immediately upstream from the coarctation. A region of small irregular vortices was formed in the first 5 to 7 mm downstream, whereas an annular vortex was observed in the region from 2.0 to 2.5 cm further downstream. Morphologic changes to the endothelium near these coarctations were assessed by scanning electron microscopy; endothelial cell replication rates as a function of time after coarctation were monitored with 3 Hthymidine. These studies established that profound alterations in endothelial cell shape caused by changes in local flow conditions immediately downstream from coarctations are primarily the result of alterations in morphology of pre-existing cells, rather than the proliferation of new cells with altered morphology. Definitive morphologic evidence of injury to endothelium was not seen at any sites after coarctation.

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Section: Discussionmentioning

confidence: 99%

Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits.

Langille¹,

Reidy²,

Kline³

1986

Arteriosclerosis

102

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“…This phenotype is also found in humans in the areas with turbulent blood flow [ 56 , 101 ]. In the zones with laminar blood flow, the overall basal rate of the EC replication is nearly negligible [ 102 , 103 ]. In our experiments, when re-endothelialization occurred over the thick BM it became faster.…”

Section: Discussionmentioning

confidence: 99%

Role of Endothelial Regeneration and Overloading of Enterocytes with Lipids in Capturing of Lipoproteins by Basement Membrane of Rat Aortic Endothelium

et al. 2022

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Atherosclerosis is a complex non-monogenic disease related to endothelial damage in elastic-type arteries and incorrect feeding. Here, using cryodamage of endothelial cells (ECs) of rat abdominal aorta, we examined the role of the EC basement membrane (BM) for re-endothelization endothelial regeneration and its ability to capture low density lipoproteins (LDLs). Regeneration of endothelium induced thickening of the ECBM. Secretion of the BM components occurred in the G2-phase. Multiple regenerations, as well as arterial hypertension and aging, also led to the thickening of the BM. Under these conditions, the speed of re-endothelialization increased. The thick BM captured more LDLs. LDLs formed after overloading of rats with lipids acquired higher affinity to the BM, presumably due to the prolonged transport of chylomicrons through neuraminidase-positive endo-lysosomes. These data provide new molecular and cellular mechanisms of atherogenesis.

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Problems with the preparation of blood vessels for scanning electron microscopy a critical review

Hollweg

Buss

1980

Scanning

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Experimentelle Untersuchungen über die Regeneration der Aortenendothelzellen

Cited by 22 publications

References 8 publications

Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits.

Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits.

Role of Endothelial Regeneration and Overloading of Enterocytes with Lipids in Capturing of Lipoproteins by Basement Membrane of Rat Aortic Endothelium

Problems with the preparation of blood vessels for scanning electron microscopy a critical review

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