Experimentelle Untersuchungen über den Schutz des Thierkörpers gegen peritoneale Infection

Hoehne, O.

doi:10.1007/bf01702308

Cited by 5 publications

(2 citation statements)

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“…The agents that produce inflammation are commonly of a bacterial or parasitic nature. A large body of experimental data (6)(7)(8)(9) leaves no doubt that bacteria are inhibited or prevented from leaving the inflamed area, within which the microorganisms tend to be dissolved or destroyed. During this process, the fate of toxic bacterial products is of the utmost importance, for these may offer greater potential dangers than the bacteria themselves.…”

Section: Discussionmentioning

confidence: 99%

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The Influence of Inflammation on the Absorption of Substances of Varied Diffusibility

Miller

1938

Journal of Experimental Medicine

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It has long been recognized that diffusible substances are absorbed from the tissues by direct entrance into the blood vessels. Dandy and Rowntree (1) made a quantitative study of absorption from the peritoneum. They found that when the diffusible dye, phenol red, is injected intraperitoneally, 40 to 60 per cent is excreted in the urine during the first hour after injection, while less than 0.1 per cent enters the thoracic lymph during this time. On the other hand, colloidal solutions and particles in suspension depend largely on the lymphatic system for absorption. Lewis (2) injected horse serum subcutaneously into a dog; using the complement fixation reaction, he was able to detect horse protein in the thoracic lymph 40 minutes after injection, while only after 3 hours did any protein appear in the blood. Drinker and Field (3) also found that horse serum is absorbed largely by way of the lymphatics. However, it should be mentioned that certain more diffusible colloidal solutions may enter the blood vessels directly. Bolton (4) found that the absorption of colloidal dyes of relatively small molecular dimensions is accomplished both by the vascular and by the lymphatic systems, but these colloidal dyes diffused into the blood more slowly than crystaUoids.Previous studies of the removal of substances from inflamed areas have dealt largely with the dissemination of bacteria. Noetzel (5) and Pawlowsky (6) found that when bacteria are injected into a joint they soon appear in the blood stream, but if the bacterial injections were made into a joint which had previously been treated by the injection of a sterile irritant, the dissemination of the bacteria was greatly inhibited. Hoehne (7) and Opie (8) found that if bacteria are injected into an inflamed peritoneal cavity, their entrance into the blood stream may be partially or completely inhibited.Interest in the absorption of soluble substances from inflamed areas was aroused by the experiments of Opie on the Arthus phenomenon. Opie (9) demonstrated that when protein is injected into the skin of a specifically immunized animal, it remains at the site of injection, where contact of antigen and antibody produce an * This paper is part of a

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Section: Discussionmentioning

confidence: 99%

“…This observation appears to parallel the experiments of Okuneff (25) who found that absorption of trypan blue from the subcutaneous tissue is accelerated when this dye is injected simultaneously with an irritant. Hoehne (7) has shown that the absorption of bacteria is similarly accelerated in the early stages of inflammation.…”

Section: Discussionmentioning

confidence: 99%