Experimentelle Untersuchungen über Asthma bronchale<sup>1</sup>

Kallós, Paul; Pagel, Walter

doi:10.1111/j.0954-6820.1937.tb16045.x

Cited by 85 publications

(3 citation statements)

References 10 publications

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“…Likewise, airway remodeling may be induced in guinea pigs. Already in the 1930s it was observed that repeated antigen challenges of guinea pigs over several weeks induced structural changes in the airways, including goblet cell hyperplasia and increased ASM mass ( [34], discussed in [35]), observations that have been confirmed and extended in more recent studies [32,[36][37][38][39][40].…”

Section: Guinea Pig Models Of Asthma: What Have We Learned?mentioning

confidence: 94%

Back to the future: re-establishing guinea pigin vivoasthma models

et al. 2020

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Research using animal models of asthma is currently dominated by mouse models. This has been driven by the comprehensive knowledge on inflammatory and immune reactions in mice, as well as tools to produce genetically modified mice. Many of the identified therapeutic targets influencing airway hyper-responsiveness and inflammation in mouse models, have however been disappointing when tested clinically in asthma. It is therefore a great need for new animal models that more closely resemble human asthma. The guinea pig has for decades been used in asthma research and a comprehensive table of different protocols for asthma models is presented. The studies have primarily been focused on the pharmacological aspects of the disease, where the guinea pig undoubtedly is superior to mice. Further reasons are the anatomical and physiological similarities between human and guinea pig airways compared with that of the mouse, especially with respect to airway branching, neurophysiology, pulmonary circulation and smooth muscle distribution, as well as mast cell localization and mediator secretion. Lack of reagents and specific molecular tools to study inflammatory and immunological reactions in the guinea pig has however greatly diminished its use in asthma research. The aim in this position paper is to review and summarize what we know about different aspects of the use of guinea pig in vivo models for asthma research. The associated aim is to highlight the unmet needs that have to be addressed in the future.

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Section: Guinea Pig Models Of Asthma: What Have We Learned?mentioning

confidence: 94%

Back to the future: re-establishing guinea pigin vivoasthma models

et al. 2020

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“…[17,18] Guineapigs were exposed to 0.5% w/v of histamine di-hydrochloride aerosol blown into the chamber through the nebulizer under 300mm Hg pressure.The end point pre convulsive dyspnea (PCD) was determined from the time of aerosol exposure to the onset of dyspnea leading to the appearance of convulsion. Any animal without pretreatment of drugs, if does not develop the typical features of asphyxia for more than three minutes, the animal was considered as resistant and such animals were excluded from the experiment.…”

Section: 4: Histamine Induced Bronchospasm In Guinea Pigsmentioning

confidence: 99%

Evaluation of Bronchoprotective Effect of Ferula Asafetida in Guinea pigs

Rath¹,

Maharana²,

Rath³

et al. 2017

IOSR JDMS

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“…Further they noted the nearly fully distended lungs floated on water. Twenty-seven years later, Kallos and Pagel [5] found marked distension of lungs from guinea pigs that died during either inhaled antigen or histamine challenge. Examples of normal versus hyperinflated guinea-pig lungs are shown in Figure 2.…”

Section: Qualitative Assessmentmentioning

confidence: 99%

Insight into Pulmonary Gas Trapping as an Index of Airway Responses in Small Laboratory Animals

Stengel¹

2014

J Drug Metab Toxicol

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Experimentelle Untersuchungen über Asthma bronchale¹

Cited by 85 publications

References 10 publications

Back to the future: re-establishing guinea pigin vivoasthma models

Back to the future: re-establishing guinea pigin vivoasthma models

Evaluation of Bronchoprotective Effect of Ferula Asafetida in Guinea pigs

Insight into Pulmonary Gas Trapping as an Index of Airway Responses in Small Laboratory Animals

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Experimentelle Untersuchungen über Asthma bronchale1

Cited by 85 publications

References 10 publications

Back to the future: re-establishing guinea pigin vivoasthma models

Back to the future: re-establishing guinea pigin vivoasthma models

Evaluation of Bronchoprotective Effect of Ferula Asafetida in Guinea pigs

Insight into Pulmonary Gas Trapping as an Index of Airway Responses in Small Laboratory Animals

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Experimentelle Untersuchungen über Asthma bronchale¹