Experimentelle Untersuchungen �ber den Situs inversus der Eingeweide und der Habenula des Zwischenhirns bei Amphibien

Woellwarth, Carl von

doi:10.1007/bf00586358

Cited by 52 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…He noted an association between reversal of organ situs and reversal of diencephalic LR asymmetry in amphibians in the wild (Von Woellwarth, 1950). Consistent with such a linkage, others have shown that Nodal signaling is required for both visceral and diencephalic LR patterning in the zebrafish.…”

Section: Coordination Of Visceral and Diencephalic Lr Asymmetrymentioning

confidence: 84%

The zebrafishnodal-related genesouthpawis required for visceral and diencephalic left-right asymmetry

2003

View full text Add to dashboard Cite

We have identified and characterized a new zebrafish gene, southpaw, that is required for visceral and diencephalic left-right asymmetry. southpaw encodes a new member of the nodal-related class of proteins, a subfamily within the transforming growth factor β superfamily of secreted factors. southpaw is expressed bilaterally in paraxial mesoderm precursors and then within the left lateral plate mesoderm. At late somite stages, left-sided southpaw expression transiently overlaps the left-sided expression domains of other genes that mark the developing heart, such as lefty2. We have injected morpholinos to block the translation of the southpaw mRNA or to block splicing of the southpaw pre-mRNA. These morpholinos cause a severe disruption of early (cardiac jogging) and late (cardiac looping) aspects of cardiac left-right asymmetry. As the left-right asymmetry of the pancreas is also affected, southpaw appears to regulate left-right asymmetry throughout a large part of the embryo. Consistent with the morphological changes, the left-sided expression domains of downstream genes (cyclops, pitx2, lefty1 and lefty2) are severely downregulated or abolished within the lateral plate mesoderm of Southpaw-deficient embryos. Surprisingly, despite the absence of southpaw expression in the brain, we find that early diencephalic left-right asymmetry also requires Southpaw activity. These observations lead to a model of how visceral organ and brain left-right asymmetry are coordinated during embryogenesis.

show abstract

Section: Coordination Of Visceral and Diencephalic Lr Asymmetrymentioning

confidence: 84%

The zebrafishnodal-related genesouthpawis required for visceral and diencephalic left-right asymmetry

2003

View full text Add to dashboard Cite

show abstract

“…The causes of the asymmetry of the HG were ascribed in part to the asymmetrical development of the parietal organ (Kuhlenbeck 1977). On the other hand, von Woellwarth (1950) observed the reversals of the usual asymmetry in the HG of the newt in cases of situs inversus of the internal organs. He suggested the existence of intimate correlation between the status of the HG and that of the internal organs, and supposed that the HG exerted influence upon the internal organs through the vagus nerve.…”

Section: Discussionmentioning

confidence: 97%

A Golgi Study on the Neuronal Organization of the Habenular Ganglion in the Red Stingray, Dasyatis akajei

Iwahori

Nakamura

Kameda

1991

Okajimas Folia Anatomica Japonica

View full text Add to dashboard Cite

Summary: The neuronal organization of the habenular ganglion (HG) was studied in the red stingray using the rapid Golgi method. The HG was made up of the medial (MH) and lateral habenular nucleus (LH), and the former nucleus was further divided into a dorsal, intermediate and ventral subnucleus. Only one type of neurons were observed in the MH, while the LH was composed of two types of neurons. In the left HG cut at the rostrocaudal middle of the ganglion, the LH was located in the dorsolateral region, while the dorsal, intermediate and ventral subnuclei of the MH occupied the dorsomedial, intermediate and ventral portions of the ganglion, respectively. In contrast, the right ganglion seen at this level was composed exclusively of the MH, with the dorsal, intermediate and ventral subnuclei located in the dorsomedial, intermediate and ventral portions, respectively. In the caudal level of the left ganglion, each nucleus was seen almost in the same region as in the level of the rostrocaudal middle, however, three subnuclei of the MH fused with the same subnuclei of the opposite side. In the right ganglion at the caudal level, the LH appeared in the intermediate area The right LH was far smaller and was located more ventrocaudally than the left LH. On account of the LH, the intermediate subnucleus of the MH was divided into a dorsal and ventral part. The dorsal and ventral subnuclei of the MH remained in the same region as in the rostral level. Thus, the HG of the red stingray exhibited a striking left-right asymmetry, the most remarkable aspect of which was considered to be differences of the size, form and location of the LH between the left and right HG.The habenular ganglion (HG) is a conspicuous structure in the dorsomedial region of the diencephalon and is known to exist in all vertebrates. One of the most remarkable features of the HG is the structural left-right asymmetry observed in certainspecies (Ariens Kappers, Huber and Crosby 1960;Kuhlenbeck 1977). The selachian HG has been known to exhibit a striking left-right asymmetry and has been the subject of numerous investigations (Edinger

show abstract

“…The complex functional asymmetries of the human brain should not be confused with the anatomical asymmetries found in the diencephalon of fishes and vertebrates (von Woellwarth 1950;Morgan 1977), which are probably controlled by the same mechanisms as control other aspects of situs (Concha et al 2000;Concha & Wilson 2001;Gamse et al 2003;Halpern et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Handedness and situs inversus in primary ciliary dyskinesia

McManus

Martin

Stubbings

et al. 2004

Proc. R. Soc. Lond. B

View full text Add to dashboard Cite

The limbs on the right side are stronger. [The] cause may be . . . [that] . . . motion, and abilities of moving, are somewhat holpen from the liver, which lieth on the right side.(Sir Francis Bacon, Sylva sylvarum (1627).)Fifty per cent of people with primary ciliary dyskinesia (PCD) (also known as immotile cilia syndrome or Siewert-Kartagener syndrome) have situs inversus, which is thought to result from absent nodal ciliary rotation and failure of normal symmetry breaking. In a study of 88 people with PCD, only 15.2% of 46 individuals with situs inversus, and 14.3% of 42 individuals with situs solitus, were left handed. Because cerebral lateralization is therefore still present, the nodal cilia cannot be the primary mechanism responsible for symmetry breaking in the vertebrate body. Intriguingly, one behavioural lateralization, wearing a wrist-watch on the right wrist, did correlate with situs inversus.

show abstract

Experimentelle Untersuchungen �ber den Situs inversus der Eingeweide und der Habenula des Zwischenhirns bei Amphibien

Cited by 52 publications

References 25 publications

The zebrafishnodal-related genesouthpawis required for visceral and diencephalic left-right asymmetry

The zebrafishnodal-related genesouthpawis required for visceral and diencephalic left-right asymmetry

A Golgi Study on the Neuronal Organization of the Habenular Ganglion in the Red Stingray, Dasyatis akajei

Handedness and situs inversus in primary ciliary dyskinesia

Contact Info

Product

Resources

About