Experimentelle und klinische Untersuchungen zur Frage der Resorption gasf�rmiger Stoffe aus dem Glask�rper

Schenk, Hanna

doi:10.1007/bf00683549

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…The surgeon ideally selects the gas on the basis of individual findings. The less soluble a gas the longer it remains within the eye (11). The larger the injected volume, the greater the expansion effect.…”

Section: Discussionmentioning

confidence: 99%

Visual Loss Following Intraocular Gas Injection

Silvanus

Moldzio²,

Bornfeld³

2008

Deutsches Ärzteblatt International

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Section: Discussionmentioning

confidence: 99%

Visual Loss Following Intraocular Gas Injection

Silvanus

Moldzio²,

Bornfeld³

2008

Deutsches Ärzteblatt International

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“…There are very few qualitative or quantitative studies on the fate of foreign materials injected into the vitreous humor. The disappearance of various gases injected into the vitreous cavity was usually estimated by ophthalmoscopy [17][18][19][20][21][22][23] or by direct measurement of the volume after the entrapment in a device of the injected gas. 24 The retention of some gases 25 and of polyacrylamide 26 was estimated by labeling the materials with radioisotopes, followed by measurements in a scintillation counter.…”

Section: Introductionmentioning

confidence: 99%

Biodegradation in vitro and retention in the rabbit eye of crosslinked poly(1‐vinyl‐2‐pyrrolidinone) hydrogel as a vitreous substitute

Hong¹,

Chirilă²,

Vijayasekaran³

et al. 1998

J. Biomed. Mater. Res.

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Abstract:To elucidate the relatively short retention of crosslinked poly(1-vinyl-2-pyrrolidinone) hydrogels in the eye when used as potential vitreous substitutes, a 14 Clabeled hydrogel was produced and subjected to both in vitro biodegradation assays and in vivo experiments. The polymer was synthesized by the free-radical copolymerization of 99% 1-vinyl-2-pyrrolidinone with 1% 14 C-methyl methacrylate in the presence of ethylene glycol dimethacrylate (0.1%) as crosslinking agent. The in vitro protocol for assessing the biodegradation included the incubation of hydrogel with hydrolases (trypsin or collagenase), followed by examination of changes in its physical characteristics and by monitoring its residual radioactivity, as well as by detection of possible degradation products. Within the maximum duration of experiments (4 weeks), none of the procedures indicated biodegradation of polymer. The hydrogel was also injected into the vitreous humor of rabbits and followed up to 4 weeks. Residual radioactivity measurements of the vitreous contents indicated that 50% of the polymer was removed by the end of this period. Histopathologic examination revealed cell infiltrates of the mononuclear phagocyte system in both vitreous and retinal tissue. A possible phagocyte-mediated mechanism for the dissipation of hydrogel is discussed.

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Physiological Chemistry of the Eye

Potts¹

1960

Arch Ophthalmol

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Experimentelle und klinische Untersuchungen zur Frage der Resorption gasf�rmiger Stoffe aus dem Glask�rper

Cited by 8 publications

References 42 publications

Visual Loss Following Intraocular Gas Injection

Visual Loss Following Intraocular Gas Injection

Biodegradation in vitro and retention in the rabbit eye of crosslinked poly(1‐vinyl‐2‐pyrrolidinone) hydrogel as a vitreous substitute

Physiological Chemistry of the Eye

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