Experimentelle und klinische Untersuchungen zum Mechanismus der Carbenoxolonwirkung. 3. Einfluß von Carbenoxolon auf die Magen-Mucussekretion des Menschen

Gheorghiu, T; Frotz, H; Klein, Hans Joachim

doi:10.1007/978-3-642-85448-4_353

Cited by 2 publications

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“…There is said to be an increased quantity of gastric mucus in the gastric mucosa after treatment with carbenoxolone sodium (Goodier, Horwich, and Galloway, 1967). Associated with this increased mucus production, there is an alteration in the molecular constitution of the mucus (Gheorghiu, Frotz, and Klein, 1971). Carbenoxolone sodium also increases the life span "Present address: Nuffield Department of Surgery, Radcliffe Infirmary, Oxford.…”

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Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

Steer¹,

Colin‐Jones²

1975

Gut

130

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SUMMARY The epithelial differences between the normal stomach (six subjects) and 47 patients with gastric ulcers were compared. The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastric ulcers were compared, and the effect of treatment with carbenoxolone sodium was studied. There is a statistically significant reduction in the total number of intraepithelial polymorphonuclear leucocytes before and after successful treatment with carbenoxolone sodium. There is also a statistically significant decrease in the quantity of intraepithelial lymphocytes in those patients with lesser curve gastric ulcers successfully treated with carbenoxolone sodium, whereas there is a significant increase in those patients with prepyloric gastric ulcers successfully treated and those patients in whom treatment failed. The value of counts of migrating white blood cells as a method of objectively assessing the effect of healing drugs upon the gastric mucosa is discussed.Pseudomonas aeruginosa was found in many specimens obtained, and evidence is presented that this was not a contaminant. Carbenoxolone appeared to increase the amount of mucus but had little effect upon the number of bacteria found. The possible contribution of Pseudomonas aeruginosa to gastric ulceration is discussed.

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Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

Steer¹,

Colin‐Jones²

1975

Gut

130

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“…Although 'positioned-release' preparations are available for treating duode nal ulcers, information regarding the effects of carbenoxolone on duodenal mucus synthe sis is limited. Although carbenoxolone treat ment has been shown to increase the number of full goblet-cells in peptic ulcer patients [4], it fails to alter the biosynthesis of duodenal mucus glycoprotein following oral adminis tration in rats [1], This communication re ports a quantitative study on the effects of carbenoxolone on gastric and duodenal mu cus synthesis in vitro and in vivo in mice.…”

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Effects of Carbenoxolone Sodium on Gastric and Duodenal Mucus Synthesis in Mice

Dai¹,

Ogle²,

Cho³

1986

Pharmacology

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Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased gastric mucus synthesis. However, in vitro study showed that carbenoxolone significantly stimulated both gastric and duodenal mucus synthesis. It is suggested that carbenoxolone may also effectively increase mucus synthesis and probably accelerate ulcer healing in the duodenum if sufficient amounts can escape gastric absorption and reach this region.

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Experimentelle und klinische Untersuchungen zum Mechanismus der Carbenoxolonwirkung. 3. Einfluß von Carbenoxolon auf die Magen-Mucussekretion des Menschen

Cited by 2 publications

References 5 publications

Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.

Effects of Carbenoxolone Sodium on Gastric and Duodenal Mucus Synthesis in Mice

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