“…(ii) The half-life in human plasma of sulfamethoxydiazine after the administration of a single dose was shown to be 36.6 h (range, 29-58 h), whereas that of sulforthomidine was 100 to 200 h (22); thus, weekly chemoprophylaxis with a longacting sulfonamide such as sulforthomidine occasionally results in the accumulation of large quantities of the drug in the tissues and could give rise to undesirable side effects (StevensJohnson syndrome). (iii) The pharmacological properties, therapeutic effects and side effects of sulfamethoxydiazine administered in large doses for 6 to 14 days or longer to more than 2,000 patients suffering from acute and chronic genitourinary tract infections, pyogenic skin infections, etc., have been studied and reported in Europe (6,11,12,15,20) and the United States (7,8,14,16,18,21,23), and sulfamethoxydiazine was found to be well tolerated.…”