Experimentelle Forschung

The Chemistry of Protein Denaturation.

“…The denaturing effects of synthetic detergents have been the subject of recent investigations. Both anionic detergents (alkyl sulfates and alkyl sulfonates, mixed alkyl-aryl sulfonates, and alkyl sulfosuccinates) (7,247,248,332) and cationic detergents (alkyl-aryl-substituted ammonium halides) (209,354) were effective, as measured by certain chemical and physical criteria. Their powerful denaturing action surpasses even that of guanidine hydrochloride when compared on the basis of equimolar concentrations (332).…”