Experimentelle Beiträge zur Pathologie des Rückenmarkes

Höche, A.

doi:10.1007/bf02322185

Cited by 33 publications

(4 citation statements)

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“…4) A series of experiments has demonstrated that metastatic abscesses in the spinal cord result from infection in an area of infarction or septic embolization. 17) Patients with congenital midline defects or anatomic abnormalities of the spinal cord or vertebral column were significantly younger than those without, which supports the view that congenital midline defects and anatomic abnormalities of the spinal cord or vertebral column are predisposing factors in pediatric ISCA, through which infection occurs. 29) All three nonsurgically treated patients with persistent or residual neurological deficits had anaerobic infections and were treated with antibiotics from 8 to 17 days after onset, and the treatment was discontinued by at most 6 weeks.…”

Section: Discussionsupporting

confidence: 66%

Intramedullary Spinal Cord Abscess Treated With Antibiotic Therapy -Case Report and Review-

Kurita

Sakurai

Taniguchi

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 58-year-old man presented with an intramedullary spinal cord abscess (ISCA) manifesting as posterior neck pain, gait disturbance, and urinary retention, and transverse myelopathy 1 week later. Magnetic resonance imaging showed the ISCA at the C7 to T1 levels. He was treated under a diagnosis of cryptogenic ISCA with high-dose ampicillin and third- or fourth-generation cephalosporins, which resulted in complete recovery after 2 months. Review of the literature between January 1998 and August 2007 identified 26 cases of ISCA, including our patient. We also identified two additional nonsurgically treated ISCA patients reported between 1977 and 2007. The most common presentation was motor deficits in all patients, followed by fever, pain, and bladder dysfunction. The mortality rate was 1 of 26 patients, and neurological sequelae were observed in 15 of the 25 surviving patients. There was no significant difference in the frequency of neurological sequelae between surgically and nonsurgically treated patients. Mean length of the abscess in the surgically treated group was significantly larger than that in the medically treated group (5.8 vs. 2.2 vertebral bodies). All three nonsurgically treated patients with neurological sequelae had anaerobic infections and received antibiotic therapy later and for shorter periods than those with complete neurological recovery. Antibiotic treatment is comparable to surgery plus antibiotic treatment. Early broad-spectrum high-dose ampicillin and third-generation cephalosporin, covering Gram-positive, Gram-negative, and anaerobic organisms, should be the first choice of management for patients with ISCA.

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Section: Discussionsupporting

confidence: 66%

Intramedullary Spinal Cord Abscess Treated With Antibiotic Therapy -Case Report and Review-

Kurita

Sakurai

Taniguchi

et al. 2009

Neurol. Med. Chir.(Tokyo)

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“…That is, the presence of PFO also indicates a high risk of ISCA not only of brain abscess 16. Hoche et al 3 17 demonstrated that the introduction of only microorganisms into the circulation of experimental animals did not result in the development of ISCA. However, if both microorganisms and thrombi were introduced, ISCA developed 3.…”

Section: Discussionmentioning

confidence: 99%

A 51-year-old man with intramedullary spinal cord abscess having a patent foramen ovale

Higuchi

Ishihara²,

Okuda³

et al. 2011

Case Reports

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“…In the preantibiotic era, 50% of the cases were due to the hematogenous spread, whereas less than 10% of the cases in modern era result by hematogenous route. 16 Tooth infection, pericolonic abscess, and suppurated lung diseases are the common sources followed by soft tissue infections and infective endocarditis. 1,3 In the present era around 25% of the cases are from contiguous spread of infection from dermal sinus tract.…”

Section: Cases and Reviewmentioning

confidence: 99%

“…17 The causative organisms in these cases include the microorganisms colonizing the skin surrounding the sinus tract openings. 16 In the lumbar region, these pathogens involve gram-negative rods, anaerobes as well as Staphylococcus species. A series of experiments have demonstrated that metastatic abscess in the spinal cord results from an infection in the area of infarction or septic embolization.…”

Section: Cases and Reviewmentioning

confidence: 99%

Intramedullary Spinal Cord Abscess: Illustration of Two Cases and Review of Literature

Chandran

Bhanuprabhakar

Sumukhan

2017

IJNS

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Intramedullary spinal cord abscess is a rare infection of the spinal cord with less than 120 cases reported since its first description by Hart in 1830. It is usually associated with abnormalities of the spinal cord or documented source of infection or immunodeficiency, requiring clinical radiological suspicion for accurate diagnosis. The first case is a middle-aged healthy woman without any underlying risk factors, presented with progressive paraparesis, in whom prompt, accurate diagnosis with contrast magnetic resonance imaging, diffusion-weighted imaging, and apparent diffusion coefficient mapping followed by early surgery was possible, which resulted in the favorable neurological outcome. The second case is a 10-year-old boy with paraparesis whose definite treatment and surgery was delayed due to a delay in accurate clinical and radiological diagnosis which resulted in poor outcomes. Hence, we try to establish that prompt diagnosis and surgical treatment can result in a favorable neurological outcome, though the prognosis, in general, is poor in this clinical condition. A review of literature in support of our cases is given.

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Experimentelle Beiträge zur Pathologie des Rückenmarkes

Cited by 33 publications

References 0 publications

Intramedullary Spinal Cord Abscess Treated With Antibiotic Therapy -Case Report and Review-

Intramedullary Spinal Cord Abscess Treated With Antibiotic Therapy -Case Report and Review-

A 51-year-old man with intramedullary spinal cord abscess having a patent foramen ovale

Intramedullary Spinal Cord Abscess: Illustration of Two Cases and Review of Literature

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