Experimentelle Beiträge zur Ätiologie und Pathogenese der Urticaria

Bruck, Carl

doi:10.1007/bf01948630

Cited by 24 publications

(3 citation statements)

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“…Specific antibodies to food proteins found in the blood of allergic individuals have given precipitates with specific antigens, and have passively sensitized normal guinea pigs (41,57,58,59).…”

Section: Lower Animalmentioning

confidence: 99%

Passage of Native Proteins Through the Normal Gastro-Intestinal Wall 1

Ratner

Gruehl²

1934

J. Clin. Invest.

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The view most generally held to-day by the physiologist, chemist and clinician is that undigested antigens are not absorbed through the normal gastro-intestinal wall; and that when such absorption does occur, it is because abnormal or pathological conditions exist, such as stasis, the excessive flooding of the intestines with protein foods, lessened activity of the digestive enzymes, altered conditions of the intestinal mucosa, and greater permeability of the intestinal wall characteristic of new-borns and sucklings. There is some evidence for the absorption of unsplit proteins under normal conditions but this is regarded as a fortuitous occurrence. In the light of the conflicting opinions present in the literature and the important role this subject plays in allergy and other conditions as yet not clearly defined, we determined to reopen the problem. PART I. ANIMAL EXPERIMENTS MethodsGuinea pigs were obtained from a reliable source. They were observed for a week and we used only those which remained healthy and gained in weight. Both young and mature animals were included in order to determine the influence of age. A large number (493) were studied in order to arrive at some approximation of the incidence of this phenomenon under the conditions to be described.We used the anaphylaxis test as the biological method of choice to determine whether native antigens had entered the blood stream from the gastro-intestinal tract. As we have previously shown (1), the Schultz-Dale uterine strip method is less reliable as an index of a state of hypersensitiveness. The difficulties in detecting foreign protein in the blood by precipitin methods are considerable, not only because the material is so greatly diluted, but, as has been frequently shown, because it leaves the blood stream so rapidly.

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Section: Lower Animalmentioning

confidence: 99%

Passage of Native Proteins Through the Normal Gastro-Intestinal Wall 1

Ratner

Gruehl²

1934

J. Clin. Invest.

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“…Before we go into these, a few words must be said, however, about the ways in which an increase in capillary permeability manifests itself microscopically and macro sopically. Bruck (1909) succeeded in producing a pronounced oedema in the part of the tongue innervated, and we have a counterpart of this reaction in the blisters formed in those areas of the human skin where the vessels are dilated in consequence of irritative processes in the corresponding spinal ganglia in the disease Herpes zoster.…”

Section: Capillariesmentioning

confidence: 72%

The Anatomy and Physiology of Capillaries.

1923

JAMA

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In 1910, Sir Arthur Pearson retired from business because of approaching blindness. When the war came he devoted his fortune to building an institution for the care and education of the war blind. This book records the work done at St. Dunstan's by Lawson, who had under his care 825 persons totally incapacitated by blindness. The book is divided into three parts: (1) traumatic blindness; (2) nontraumatic blindness; (3) pensions and reeducation of the blind. There were 407 traumatic cases: 72 caused by bullets passing through the orbits, 17 of fracture of the occipital portion of the skull, 12 of fracture of the skull other than occipital, 16 of concussion blindness without direct wound or penetration of the globe, and 289 miscellaneous cases of blindness from premature explosions of bombs, explosive bullets, aeroplane accidents and burns. There was a notable absence of sympathetic inflammation. There were 417 cases of nontraumatic blindness, a review of which led to some conclusions concerning enlistment. In the examination of men for military ser¬ vice, those who have had disease of the uveal tract of both eyes should be rejected. When only one eye is involved, as the result of traumatic uveal inflammation, the man should not be accepted. A careful ophthalmologic examina¬ tion should be made to rule out congenital disease, such as retinitis pigmentosa, or some chronic disease, such as chorioretinitis, thus saving the state much money in pensions. Interstitial keratitis and other varieties of inflammatory dis¬ ease were found in 138 cases, of which 47 were interstitial. There were 109 cases of primary optic nerve disease, of which 62 were positively the result of syphilis and 18 more were clinically so classified. Secondary optic nerve degeneration gave 44 cases due to syphilis, cerebral tumor and meningitis.Blindness due to detachment of the retina was found in 29 cases; family atrophy, in 17; glaucoma, in 11; cataract, in 7; traumatic neurasthenia, in 4; bilateral embolism of the central retinal artery, in 2, and pituitary disease in 3. There was one each of recurrent retinal hemorrhage, exophthalmic goiter, retinitis proliferans and meningitis. Syphilis as a cause of nontraumatic blindness in the war is well shown by this review. The third part deals with pensions and the reeduca¬ tion of the blind. The author well contends that men blinded by disease brought on by unfavorable conditions in the war should be pensioned. The question of syphilis and war blind¬ ness was finally settled so that men were given pensions who had loss of vision due to a syphilitic lesion, acquired or congenital, with or without a positive Wassermann reaction. That section of the book dealing with reeducation is brief, and gives an accurate picture of the difficulties and problems of this phase of the work among the war blind which ought to be known by every ophthalmologist. Trait\l=e'\pratique de cystoscopie et de cath\l=e'\t\l=e'\rismeur\l=e'\t\l=e'\ral. Par G. Marion, Professeur agr\l=e'\ge \l=a`\la Facult\l=e'\,Chirurgien de l'H\l=...

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“…These vasodilator reactions call to mind the "antidromic" vasodilatation produced in the legs of mammals by mechanical stimulation of the sciatic and shown (Bayliss, 1901 and 1902) to be localized in posterior root fibres. Bayliss' experiments have given no definite proof that the capillaries are involved in his 1 1 have not succeeded in producing this capillary hyperemia by electric stimulation, but I find that Bruck (1909) has obtained it in one half of the tongue by faradie stimulation of the corresponding glossopharyngeal nerve.…”

Section: Structure Of the Capillary Wall 67mentioning

confidence: 87%

The Anatomy and Physiology of Capillaries.

1929

JAMA

251

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also steadily maintained at about the size of recent editions has once more been skilfully managed. Undulant fever has its first mention ; the sections on dengue fever, pulmonary abscess and ulcerative colitis have been rewritten, and plates VI and VII, illustrating the roentgenoscopic features of pulmonary disease, are new ; also many other illustrations. On the whole, only alterations in keeping with studious attention to the needs of yearly revisions have been made.

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Experimentelle Beiträge zur Ätiologie und Pathogenese der Urticaria

Cited by 24 publications

References 0 publications

Passage of Native Proteins Through the Normal Gastro-Intestinal Wall 1

Passage of Native Proteins Through the Normal Gastro-Intestinal Wall 1

The Anatomy and Physiology of Capillaries.

The Anatomy and Physiology of Capillaries.

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