Experimentelle Beiträge zur Aetiologie und Therapie der Epilepsie

Ito, Hiroki

doi:10.1007/bf02791982

Cited by 8 publications

(6 citation statements)

References 92 publications

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“…Postoperatively, a significant decrease in seizure frequency and a verifiably reduced ICP was observed. Ito concluded that the tapping‐induced functional hyperemia of the central nervous system (CNS) led to an increase in ICP, which finally caused the epilepsy (Ito, 1899). Because no structural brain damage was found in the epileptic guinea pigs, Kocher felt vindicated in his conviction of a key role for elevated ICP in the genesis of epilepsy.…”

Section: Efforts To Find Evidence In Support Of Kocher’s Theorymentioning

confidence: 99%

Emil Theodor Kocher—Valve surgery for epilepsy

2012

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Summary Emil Theodor Kocher (1841–1917) was a pioneering and versatile Swiss surgeon who played a decisive role in the surgical evolution on the threshold to the 20th century. Apart from conducting intense research and fostering the development of the surgical treatment of thyroid gland diseases (honored with a Nobel Prize in 1909), he remained a generalist and was active in orthopedic, genitourinary, and neurologic surgery. Even today, many surgical techniques and instruments are still named after him, thus providing evidence of his great impact. His neurosurgical ambitions included, in particular, cerebral and spinal trauma, the pathophysiology of elevated intracranial pressure, as well as etiological considerations and the operative treatment of epilepsy. This article aims to shed light on Kocher’s work on epilepsy, published exclusively in German, and illustrates the development of his idea on valve surgery for recurrent general convulsions.

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Section: Efforts To Find Evidence In Support Of Kocher’s Theorymentioning

confidence: 99%

Emil Theodor Kocher—Valve surgery for epilepsy

2012

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“…Ito (1899) included a detailed account of the earlier published work on attempts to produce convulsing in animals in a long two‐part paper that contained numerous extracts from the original literature. This paper provides a convenient access to a considerable amount of the earlier European language literature on experimental epileptology.…”

Section: The 19th Centurymentioning

confidence: 99%

“…There were 19th century reports of the occasional use of other methods of invoking convulsing in experimental animals, for example, centrifuging the whole animal body, cerebral freezing, and localized cerebral heating (Ito, 1899).…”

Section: The 19th Centurymentioning

confidence: 99%

“…At autopsy, there were small hemorrhages in the medulla oblongata and upper parts of the spinal cord in his animals. Ito (1899), who studied the role of raised intracranial pressure in producing epileptic seizures, achieved immediate convulsing by inserting objects such as paraffin wax, glass balls, glass fragments, and laminaria sticks into subcortical areas of the brains of guinea pigs. However, he could not achieve a satisfactory experimental model of ongoing recurrent unprovoked seizures.…”

Section: Mechanical Stimulationmentioning

confidence: 99%

“…Weeks to months after such surgery, ongoing apparently spontaneous convulsive attacks sometimes occurred in surviving animals. Later, Ito (1899) reported that two of Luciani's surviving dogs had been mated after their surgery; five of their eight offspring developed seizures and died in status epilepticus, raising the possibility that the experimentally produced seizure disorder might be inheritable, although other interpretations are possible.…”

Section: Strategic Removal Of Cerebral Cortical Areasmentioning

confidence: 99%

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Experimental epileptology before 1900

Eadie

2009

Epilepsia

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SUMMARYThe available English and other major Western European language literature was reviewed to assess the stage of development of experimental epileptology prior to the end of the 19th Century. The relevant investigations had been carried out in animals of various species employing a number of methods of evoking convulsive seizures, mainly mechanical, electrical or chemical stimulation or surgical removal of parts of the cerebral cortex. The studies had produced some conflicting data but (i) allowed the development of a number of reasonably satisfactory experimental models of convulsive epileptic seizures (ii) confirmed that such epileptic seizures arose from the cerebral cortex, and (iii) suggested that for local onset epileptic seizures to become generalised tonic-clonic ones, the opposite motor cortex and probably a brain stem, possibly pontine, centre needed to be involved. No generally acceptable animal model of chronic epilepsy had been developed, and the non-motor manifestations of epileptic seizures were still largely unexplored experimentally. Nevertheless, the pre-1900 investigations not only laid the foundations for the 20th Century expansion of experimental studies on epileptogenesis but also advanced the understanding of epileptic seizure production.

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Ein Beitrag zur operativen Behandlung der traumatischen Epilepsie

Kolaczek

1913

Deutsche Zeitschrift f. Nervenheilkunde

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Ein Beitrag zur operativen Behandlung der traumatisehenEpilepsie.)'on Dr. Hans Kolaczek, Privatdozent 9 Chirurgie, Assistenzarzt der med. Klinik in Breslau von 1904Breslau von --1906 Noch immer ist die allgemeine genuine Epilepsie eine der un-gekl~rtesten Krankheiten des Zentra]nervensystems, ~tiologisch wenn man von der ja zweifellosen Bedeutung der Erblichkeit absieht --r~tse]haft und therapeutisch --von der ja sicher vorhandenen, aber doch unbefriedigenden Einwirkung des Broms abgesehen --unangreifbar. Auch pathologiseh-anatomisch galt sie bis vor nicht zu langer Zeit als unbekanntes Land, bzw. als ein solches, wo trotz eifrigem Suchen nichts gefunden worden war, so dass sie schlankweg unter die Neurosen ohne oder ohne bekannte anatomische Grund]agen eingereiht wurde. Und Binswanger hielt es ,,geradezu fiir einen Riickschritt der patho]ogisch-physiologischen Erkenntnis, wenn man Mle St6rungen der Nervenfunktion, jener ausserordentlich feinen,-auf bestimmte physiologische Reize abgestimmten T~tigkeits~usserungen des Zentralnervensystems immer wieder ausschliesslich auf grobe Ver-~nderungen der Nervensubstanz zuriickfiihren will." Demgegeniiber sind seit Chas]ins ersten Untersuchungen im Jahre 1889 immer wieder Untersuchungen gemacht worden zur Auffindung pathologisch-anatomischer Ver~nderungen bel der Epilepsie, die neuesten, zahlreichsten und genauesten von Alzheimer an 63 Epileptikergehirnen. Er fand konstant --wenn auch je nach dem Alter des Falles, d. h. seit der Zeit des Bestehens der Epilepsie, von verschiedener Intensit~t --eine Randgliose der Hemisph~ren, die er a]s Folge einer Degeneration nervSsen Rindengewebes, der Markfasern und Ganglienzellen, ansieht. Auerbach vergleicht in einer neueren Arbeit diese Befunde mit denen bei der nicht eitrigen EncephMitis, und kommt so zu der Ve 9 dass auch die anatomischen Befunde bei der genuinen Epilepsie nichts anderes sein kSnnen als der anatomische Ausdruck ganz leichter, oberfl~chlicher und in Schiiben verlaufender Enceph" So beme 9diese BeIunde und anschliessenden Hypothesen iiir die Pathogenese der genuinen Epilepsie sind, so wenig l~sst sich mit ihnen Ein Beitrag zur operativen Behandlung der traumatischen Epilepsie. 313

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Experimentelle Beiträge zur Aetiologie und Therapie der Epilepsie

Cited by 8 publications

References 92 publications

Emil Theodor Kocher—Valve surgery for epilepsy

Emil Theodor Kocher—Valve surgery for epilepsy

Experimental epileptology before 1900

Ein Beitrag zur operativen Behandlung der traumatischen Epilepsie

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