Experimentelle Beitr�ge zur Frage der Zusammenh�nge: Regenerationsf�higkeit ? Geschwulstbildung

Seilern-Aspang, F.

doi:10.1007/bf00576348

Cited by 19 publications

(5 citation statements)

References 12 publications

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“…The tissues produced are indentical to those of untreated limbs, exhibiting the same local spatial relationships, even in abnormal regenerates. In this respect, the preceding re sults agree with previous ones obtained from several laboratories [6,[9][10][11][12],…”

Section: Discussionsupporting

confidence: 92%

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Evidence that Chemical Carcinogens Interfere with Specific Regeneration-Controlling Mechanisms of Urodeles

Koussoulakos¹

1992

Tumor Biol

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The present investigation was conducted in an attempt to understand the interrelationships between carcinogenesis and regeneration. The aim was to find out whether chemical carcinogens constitute a class of agents specifically interfering with the normal developmental process during amphibian limb regeneration. To achieve this, the potent chemical carcinogens N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and N-nitrosodimethylamine (DMN) were inserted at a position slightly proximal to the blastema of regenerating Triturus cristatus forelimbs. The results indicate that, sometimes, the two developmental parameters, growth rate and morphogenesis, were differently affected depending on the treated limb and the carcinogen used. The effect of DMN on regenerative growth rate was negligible, but morphogenesis was highly impaired. Similarly, MNNG-treated stumps displayed abnormal regenerates in both forelimbs, whereas growth rates were significantly affected only in the right forelimbs. The findings are discussed in the framework of the relevant hypotheses.

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Section: Discussionsupporting

confidence: 92%

“…Interest was further stimu lated when it was epidemiologically and ex perimentally revealed that regeneration and carcinogenesis share several fundamental bio-logical properties [4][5][6]. They both start by dedifferentiation of organized tissues, and proceed by vigorous proliferation of the de differentiated cells [7,8].…”

Section: Introductionmentioning

confidence: 99%

Evidence that Chemical Carcinogens Interfere with Specific Regeneration-Controlling Mechanisms of Urodeles

Koussoulakos¹

1992

Tumor Biol

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“…Sometimes super-numerary organs like little tails developed. 110 Similar observations were made in other powerful regeneration models, such as the lenses and iris or limbs from newts, showing that the autonomous growth of malignant cells can be brought under control or reintegrated into the biological system by the regenerative process. 111 – 113 Correspondingly, an impaired, incomplete, or uncoordinated regenerative process after chronic injury or inflammation can give rise to a malignant tumor.…”

Section: Cancer and Embryology And Tissue Renewalsupporting

confidence: 56%

“…105 Interestingly, the ability to develop cancer is inversely correlated to the propensity for regeneration: Cancer has been found only in animals with a low or absent regenerative capacity of complete limbs or head, while animals with a strong ability to rebuild lost limbs hardly ever develop cancer. [106][107][108][109][110] This is especially noticeable in hydra, which can replace all limbs without any difficulties. It can be split in many small particles which assemble again to a new organism.…”

Section: Tumor Tissue As a Populationmentioning

confidence: 99%

From Reductionism to Holism: Systems-oriented Approaches in Cancer Research

Kienle

Kiene

2012

Glob Adv Health Med

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Somatic mutation theory of cancer has directed cancer research during the last century. A deluge of information on cellular, molecular, and genetic behavior was uncovered, but so was a mind-numbing complexity that still challenges research and concepts, and expectations in the war on cancer have by and large not been fulfilled. A change of paradigm beyond reductionism has been called for, especially as research ubiquitously points at the importance of tissue, microenvironment, extracellular matrix, embryonic and morphogenetic fields, and fields of tissue maintenance and organization in the processes of carcinogenesis, cancer control, and cancer progression, as well as in the control of cellular and genetic behavior. Holistic, organismic systems concepts open new perspectives for cancer research and treatment, as well as general biological understanding.

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“…The induction of abnormal differentiation and neoplasia in planarians by action of carcinogens has been studied by many investigators (Goldsmith, 1939(Goldsmith, , 1941Gersch, 1951;Seilern-Aspang, 1960a, 1960b, 1961Ohba, 1961;Seilern-Aspang & Kratochwil, 1962, 1963a, 1963bFoster, 1963Foster, , 1969Lange, 1966;Hall et al, 1986;and others). Most recently, Hall et al (1986) induced neoplasia at high frequency in Dugesia dorotocephala by applying cadmium sulfate and TPA (12-O-tetradecanoyl-phorbol-13-acetate) and by transplanting neoplastic tissue into normal worms.…”

Section: Introductionmentioning

confidence: 99%

Formation of malformed pharynx and neoplasia in the planarian Bdellocephala brunnea following treatment with a carcinogen

Hoshina¹,

Teshirogi²

1991

Hydrobiologia

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The effect of benzo(a)pyrene on regeneration of the pharynx in Bdellocephala brunnea Ijima et Kaburaki was studied by inserting a 5-pg crystal of this carcinogen into the pharyngeal cavity of worms from which the pharynx had been extirpated 2 d previously. Multiple pharynges formed in the regenerates, and neoplasia was induced in a few cases. The malformed pharynges appeared as protrusions overlapping the anterior part of the main pharynx. Electron microscopy of the pharynx in normal, intact worms shows eight layers comprising inner and outer ciliated epithelia, muscle, and glands.

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Experimentelle Beitr�ge zur Frage der Zusammenh�nge: Regenerationsf�higkeit ? Geschwulstbildung

Cited by 19 publications

References 12 publications

Evidence that Chemical Carcinogens Interfere with Specific Regeneration-Controlling Mechanisms of Urodeles

Evidence that Chemical Carcinogens Interfere with Specific Regeneration-Controlling Mechanisms of Urodeles

From Reductionism to Holism: Systems-oriented Approaches in Cancer Research

Formation of malformed pharynx and neoplasia in the planarian Bdellocephala brunnea following treatment with a carcinogen

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