Experimentelle Beeinflussung der granulierten Zellen des juxtaglomerul�ren Apparates durch Heminephrektomie und bilaterale Ureterligatur

Endes, P; Devenyi, I; Gomba, S

doi:10.1007/bf00957637

Cited by 7 publications

(1 citation statement)

References 10 publications

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“…Increased juxtaglomerular cell granulation in the remaining kidney after unilateral nephrectomy has previously been observed both in mice (Tverdy, 1955) and rats (Endes, DBvBnyi & Gomba, 1962). The latter authors noted that this increase in granulation was preceded by a phase of decreased granulation 6 to 24 hours after the nephrectomy, and that after about one month of hypergranulation subnormal JGI values were slowly reassumed.…”

Section: Discussionmentioning

confidence: 80%

The Early Effect of Unilateral Nephrectomy on the Degree of Juxtaglomerular Cell Granulation and Blood Pressure in the Rat

Ljungqvist

Wågermark

1968

Scandinavian Journal of Urology and Nephrology

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The early effect of unilateral nephrectomy on the blood pressure and the degree of juxtaglomerular cell granulation in the remaining kidney was investigated in the rat. No blood pressure alterations were recorded during the experimental period (64 days). The remaining kidney showed a slight increase in the degree of juxtaglomerular cell granulation which was evident throughout the experimental period. The findings indirectly suggest that the increase in juxtaglomerular cell granulation apparent in the untouched kidney two weeks after removal of the clipped kidney in the hypertensive rat is to a certain, although probably minor, degree a compensatory feature due to the nephrectomy. Scand J Urol Nephrol Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/02/14For personal use only. Further observations on juxtaglomerular cells and renal pressor activity in experimental hypertension. LabInvest 13, 321. Scand J Vrol Nephrol2Scand J Urol Nephrol Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/02/14For personal use only.A simple method for determining the systolic pressure of the unanesthetized rat. I CIin Invest 18, 373. Scand J Urol Nephrol2Scand J Urol Nephrol Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/02/14For personal use only.

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Section: Discussionmentioning

confidence: 80%

The Early Effect of Unilateral Nephrectomy on the Degree of Juxtaglomerular Cell Granulation and Blood Pressure in the Rat

Ljungqvist

Wågermark

1968

Scandinavian Journal of Urology and Nephrology

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Ultrastructure, renin status, contractile and electrophysiological properties of the afferent glomerular arteriole in the rat hydronephrotic kidney

Nobiling¹,

Bührle²,

Hackenthal

et al. 1986

Vichows Archiv A Pathol Anat

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Histological, ultrastructural, immunohistochemical, intravital microscopic and electrophysiological techniques have been applied to study experimental hydronephrosis in rats in order to assess its value as a preparation for the investigation of renal microcirculation and of the electrophysiological properties of the renin-containing juxtaglomerular (JG) cells of the afferent glomerular arteriole. As hydronephrosis develops, the kidney parenchyma becomes progressively thinner owing to tubular atrophy. Twelve weeks after ureteral ligature, this process results in a transparent tissue sheet of about 150-200 microns in thickness. In this preparation, the renal arterial tree as well as the glomeruli can be easily visualized for intravital microscopic studies, e.g. the determination of kidney vessel diameters, or the identification of JG cells for penetration with an intracellular microelectrode. In contrast to the tubular atrophy, the vascular system is well preserved, and the JG cells and the sympathetic axon terminals are ultrastructurally intact. This is also true for the glomeruli, except for a certain confluence of the podocyte foot processes and a thickening of the basal laminae. Renin immunostaining and kidney renin content in the hydronephrotic organ correspond to those in control kidneys. In addition, there are no differences in the plasma renin levels of hydronephrotic and control rats. Intravital microscopic observations reveal that the renal vascular tree reacts in a typical, concentration dependent manner to the vasoconstrictor agent angiotensin II, mainly at the level of the resistance vessels. Electrophysiological recordings from juxtaglomerular granulated cells show a high membrane potential (-60 mV), and spontaneous depolarizing junction potentials, owing to random transmitter release from the nerve terminals. Angiotensin II, an inhibitor of renin release, depolarizes JG cells reversibly. Hence, we may infer that the hydronephrotic rat kidney is a suitable model for in vivo studies of the renal microcirculation as well as for in vitro investigations of the electrophysiological properties of the media cells of the afferent glomerular arteriole.

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Regenerative processes in the kidneys of rats in late stages after operation

Farutina

1965

Bull Exp Biol Med

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Experimentelle Beeinflussung der granulierten Zellen des juxtaglomerul�ren Apparates durch Heminephrektomie und bilaterale Ureterligatur

Cited by 7 publications

References 10 publications

The Early Effect of Unilateral Nephrectomy on the Degree of Juxtaglomerular Cell Granulation and Blood Pressure in the Rat

The Early Effect of Unilateral Nephrectomy on the Degree of Juxtaglomerular Cell Granulation and Blood Pressure in the Rat

Ultrastructure, renin status, contractile and electrophysiological properties of the afferent glomerular arteriole in the rat hydronephrotic kidney

Regenerative processes in the kidneys of rats in late stages after operation

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