Experimentally produced synovial sarcomas

Ghadially, F. N.; Roy, S. C. Dutta

doi:10.1002/1097-0142(196612)19:12<1901::aid-cncr2820191218>3.0.co;2-h

Cited by 24 publications

(4 citation statements)

References 9 publications

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“…One of the first such reports was that of Ghadially and Roy, published in 1966, in which these sarcoma researchers were able to induce the development of synovial sarcoma by injecting dimethyl-benzanthracene (DMBA) into the knee joint of rats. 9 One final example of groundbreaking sarcoma research that first appeared in Cancer was an initial report concerning the detection of tumor-associated antigens in soft tissue sarcoma, written by Eilber and Morton in 1970. 10 The sera from patients bearing a variety of soft tissue and skeletal sarcomas could be demonstrated to contain antibodies to a sarcomaspecific antigen retrieved from a cultured human liposarcoma cell line.…”

Section: Sarcoma Clinical and Research Biologymentioning

confidence: 99%

The seminal role ofCancerin our understanding of sarcoma

Pollock

2008

Cancer

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The journal Cancer has played a critical role in advancing our understanding of sarcoma, a remarkable cluster of malignancies that arise from tissues of KEYWORDS: sarcoma, prognostic factors, staging systems, therapy for sarcoma. Because of the relative rarity of malignant disease of the connective tissue, over the past 60 years the study of sarcoma has been hampered by a lack of the patient and tumor resources needed to derive definitive conclusions. As compared with the more common malignancies of epithelial origin, there are relatively fewer centers in which basic, translational, clinical, and outcomes research focusing on sarcoma has been conducted. Nonetheless, students of sarcoma have found a receptive podium and audience under the aegis of Cancer, and it is striking that many of the classic and critical sarcoma reports of the past 60 years have seen the light of day via this journal. Moreover, many key developments over this same time period in the much larger field of oncology have been the result of groundbreaking sarcoma reports that have appeared in Cancer. Subjects as diverse as the viral and chemical etiology of solid tumors, the oncogenic impact of anticancer therapies, multimodality therapy of cancer, neoadjuvant systemic approaches to malignancy, function-preserving surgery, clinical and molecular prognosis, and the development of staging systems are all examples of critical concepts introduced by sarcoma-oriented research reports that have appeared in Cancer over the past 60 years. The contributions in 3 broad categories of emphasis will form the basis of this review article. These include: sarcoma clinical and research biology, sarcoma prognosis and staging, and the treatment of sarcoma. Greater than 150 sarcoma research reports have appeared in Cancer to date. In keeping with the historical orientation of this review, this analysis will focus on contributions that have had a significant impact in sarcoma oncology, particularly highlighting reports that are more than 30 years All quotations were reprinted with the permission

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Section: Sarcoma Clinical and Research Biologymentioning

confidence: 99%

The seminal role ofCancerin our understanding of sarcoma

Pollock

2008

Cancer

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“…Aflatoxin, the responsible chemical agent, was identified and traced to contamination of the nuts by a fungus, Aspergillus flavus . In the 1960s, nitrosamines, benzanthracene, and a number of other compounds were added to the long list of organ‐specific carcinogens in experimental animals. These discoveries were followed by the incontrovertible confirmation that exogenous estrogen is capable of inducing mammary carcinoma in several different species of laboratory animals…”

Section: Introductionmentioning

confidence: 99%

A note from history: Landmarks in history of cancer, Part 6

Hajdu

Vadmal

2013

Cancer

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In the 3 decades from 1940 to 1970, the United States became the nucleus for research, diagnosis, and treatment of cancer. The discovery of anticancer drugs, and the clinical demonstration that chemotherapy and radiation can cure cancer and have the ability to prevent recurrence of cancer, were incontrovertibly the most remarkable groundbreaking events. Consequently, the trend of less surgery and more multimodality therapy began. The introduction of radioautography, mammography, ultrasonography, computed tomography, Papanicolaou smear, and other novel laboratory tests furthered early detection of cancer and refined accurate diagnosis. The unequivocal linking of lung cancer to cigarette smoking made medical history. The delineation of the potential role of oncogenes adduced new thoughts about oncogenesis and cancer prevention, and pathologists finalized the classification and nosology of tumors. Finally, it is worth noting that although more advances were made in the detection, diagnosis, and treatment of cancers than any other period in history, the overall mortality rate of patients with cancer remained high and unchanged. Cancer 2013;119:4058-82.V C 2013 American Cancer Society.KEYWORDS: history of cancer, history of medical oncology, history of surgical oncology, history of radiation therapy, history of diagnostic radiology, history of surgical pathology, history of cytopathology, history of cancer research, history of immunology, history of cancer epidemiology and cancer institutions.

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“…Synovial sarcoma is a malignant tumour of mesenchymal origin, occurring mainly in the vicinity of the joints of the extremities. Most often the tumour arises in soft tissue outside the joint capsule, but may invade the joint later (3,7,(9)(10)(11)(12)14). Tendon sheaths and bursae are rarely the site of origin, but the neoplasm usually invades them in the process (7,9,10,12,14).…”

Section: Introductionmentioning

confidence: 99%

“…Also, subsequent invasion of the adjacent bones may occur (9,11,12,14). Furthermore, it is supported that synovial sarcoma can arise from any mesenchy-ma1 cell which has the power to differentiate into synovial structures (2,3). Thus, synovial sarcomas have been reported in sites remote from joints, as the neck, the abdominal and the chest wall (1-3, 7, 14).…”

Section: Introductionmentioning

confidence: 99%

Synovial Sarcoma in a Dog

Karayannopoulou

Kaldrimidou

Dessiris

1992

Journal of Veterinary Medicine Series A

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Summary Synovial sarcoma is an uncommon malignant tumour of mesenchymal origin, occurring mainly in the vicinity of a joint. Subsequent invasion of the joint and adjacent bones may occur. Less frequently the tumour may be localized in soft tissues remote from joints. Synovial sarcoma usually affects male middle‐aged dogs of large breeds. The rate of tumour growth can vary from very slow to very rapid. The tumour is usually poorly defined and infiltrates the deeper structures. Metastasis and recurrence are common. Wide‐field surgical excision of the tumour or amputation of the affected limb are the most frequently used forms of treatment. In the present case the dog, a 7‐year‐old male Alsatian, had a slowly growing tumour in the vicinity of the hip joint, bilaterally. There was no involvement of the bones surrounding the tumour. Surgical resection was performed and one year later the dog was reported to be normal.

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Experimentally produced synovial sarcomas

Cited by 24 publications

References 9 publications

The seminal role ofCancerin our understanding of sarcoma

The seminal role ofCancerin our understanding of sarcoma

A note from history: Landmarks in history of cancer, Part 6

Synovial Sarcoma in a Dog

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