Experimentally induced cytauxzoonosis-like disease in domestic cats

Wagner, Joseph; Ferris, D. H.; Kier, Ann B.; Wightman, S.R.; Maring, E.; Morehouse, L. G.; Hansen, Rowena

doi:10.1016/0304-4017(80)90075-8

Cited by 72 publications

(89 citation statements)

References 2 publications

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“…Small piroplasms reported from felids include Babesia felis (12), reported for African wild cats (Felis sylvestris ocreata) and caracals (Felis caracal) (38) in Africa; Babesia leo, reported for lions (Panthera leo) in South Africa (38) and Tanzania (32); and Cytauxzoon felis, reported for domestic cats and bobcats (Lynx rufus) (15,45), mountain lions (Felis concolor), and Florida panthers (Felis concolor coryi) (7,41) in North America.…”

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Babesia lengau sp. nov., a Novel Babesia Species in Cheetah ( Acinonyx jubatus , Schreber, 1775) Populations in South Africa

et al. 2010

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In a previous paper, we reported on a large number of cheetah blood specimens that gave positive signals only for Babesia and/or Theileria genus-specific probes on the reverse line blot (RLB) assay, indicating the presence of a novel species or variant of an existing species. Some of these specimens were investigated further by microscopic, serological, sequencing, and phylogenetic analyses. The near-full-length 18S rRNA genes of 13 samples, as well as the second internal transcribed spacer (ITS2) region, were amplified, cloned, and sequenced. A species-specific RLB probe, designed to target the hypervariable V4 region of the 18S rRNA gene for detection of the novel Babesia sp., was used to screen an additional 137 cheetah blood specimens for the presence of the species. The prevalence of infection was 28.5%. Here we describe the morphology and phylogenetic relationships of the novel species, which we have named Babesia lengau sp. nov.

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Babesia lengau sp. nov., a Novel Babesia Species in Cheetah ( Acinonyx jubatus , Schreber, 1775) Populations in South Africa

et al. 2010

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“…Of the large (Ͼ2.5 m) piroplasms reported from felids, Babesia cati (Mudaliar et al, 1950) was recovered from a domestic cat in India, B. herpailuri (Denning, 1967), from a jaguarundi (Felis yagouaroundi) in Central America, and B. pantherae (Denning and Brocklesby, 1972) from a leopard (Panthera pardus) in Africa. The small (Ͻ1.5 m) piroplasms reported from felids include B. felis (Davis, 1929) first described from a African wild cat (Felis sylvestris ocreata), Cytauxzoon felis from domestic cats and bobcats (Lynx rufus) (Wagner, 1976;Glenn et al, 1983), mountain lions (Felis concolor) and Florida panthers (Felis concolor coryi) (Butt et al, 1991;Rostein et al, 1999) in North America, and B. leo from lions (Panthera leo) in South Africa (Penzhorn et al, 2001). Several additional unidentified piroplasm have been reported from a variety of felid hosts (Wenyon and Hamerton, 1930;Stewart et al, 1980;Zinkl et al, 1981;Averbeck et al, 1990).…”

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An Intraerythrocytic Small Piroplasm In Wild-caught Pallas's Cats (Otocolobus manul) from Mongolia

Ketz-Riley

Reichard

Bussche

et al. 2003

Journal of Wildlife Diseases

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During the quarantine examination of four Pallas's cats (Otocolobus manul) imported from Mongolia in October and December 2000, intraerythrocytic piroplasms were detected on Wright-Giemsa stained blood films that were morphologically indistinguishable from other small piroplasms of felids. Further characterization of this unknown organism via polymerase chain reaction amplification, sequencing of a portion of the 18S nuclear small subunit rRNA gene, and comparisons with orthologous sequences from other piroplasms, revealed similarity to Cytauxzoon felis. This is the first report of naturally occurring erythroparasitemia in Pallas's cats and the first documented case of naturally occurring piroplasm infections in a free-ranging felid from Mongolia.

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“…1 The disease was originally reported in 1976 in a domestic cat from Missouri. 2 Subsequently, the disease has been reported in several states, including Arkansas, Oklahoma, Texas, Georgia, Mississippi, Louisiana, and Florida. 1 Cytauxzoon felis, the causative agent, has both an erythrocytic phase and a schizogenous tissue phase that develops in macrophages within many organs of the body, most prominently lung, spleen, liver, and lymph nodes.…”

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Cats Surviving Natural Infection withCytauxzoon felis: 18 Cases (1997–1998)

Meinkoth

Kocan

Whitworth

et al. 2000

Veterinary Internal Medicne

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Eighteen cats surviving natural infection with Cytauxzoon felis were identified. All cats came from a limited geographic area in northwestern Arkansas and northeastern Oklahoma. Clinical signs in most cats were similar to those described for cytauxzoonosis; however, 4 cats were asymptomatic. All cases were initially diagnosed by microscopic identification of signet ring-shaped piroplasms in erythrocytes of peripheral blood smears. Four of 4 cats tested had detectable serum antibodies to C felis. Four different cats were positive by polymerase chain reaction (PCR). Partial sequencing of the PCR product from 1 cat revealed Ͼ99% homology with the reported sequence of C felis. Repeated examination of blood smears from 12 cats revealed that the erythroparasitemia was generally persistent for the duration of follow-up (3-154 days). Survival did not seem dependent on treatment, as only 1 cat was treated with a drug with potential antiprotozoal activity (imidocarb dipropionate), and 4 cats received no treatment. The findings of this study may indicate the existence of a less virulent strain of C felis.

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Experimentally induced cytauxzoonosis-like disease in domestic cats

Cited by 72 publications

References 2 publications

Babesia lengau sp. nov., a Novel Babesia Species in Cheetah ( Acinonyx jubatus , Schreber, 1775) Populations in South Africa

Babesia lengau sp. nov., a Novel Babesia Species in Cheetah ( Acinonyx jubatus , Schreber, 1775) Populations in South Africa

An Intraerythrocytic Small Piroplasm In Wild-caught Pallas's Cats (Otocolobus manul) from Mongolia

Cats Surviving Natural Infection withCytauxzoon felis: 18 Cases (1997–1998)

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